Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain

Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain

Abstract Background Long-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior cingulate cortex (ACC) has been demonstrated to be associated with pain and substance abuse. This study aims to investigate whether ACC microglia...

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Bibliographic Details
Main Authors: Dan-dan Long, Yu-zhuo Zhang, An Liu, Liang Shen, Hong-rui Wei, Qian-qian Lou, Shan-shan Hu, Dan-yang Chen, Xiao-qing Chai, Di Wang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Neuroinflammation
Subjects:
Chronic nicotine
Pain
Anterior cingulate cortex
Microglia
Glutamatergic neurons
CX3CL1
Online Access:https://doi.org/10.1186/s12974-023-02767-0

Internet

https://doi.org/10.1186/s12974-023-02767-0

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