Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville
<p>Abstract</p> <p>Background</p> <p>Congo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line and second-line anti-malarial drugs to treat uncomplicated <it>Plasm...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-02-01
|
| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://www.malariajournal.com/content/12/1/53 |
| _version_ | 1818513725434363904 |
|---|---|
| author | Ndounga Mathieu Mayengue Pembe Issamou Casimiro Prisca Nadine Loumouamou Dieudonné Basco Leonardo K Ntoumi Francine Brasseur Philippe |
| author_facet | Ndounga Mathieu Mayengue Pembe Issamou Casimiro Prisca Nadine Loumouamou Dieudonné Basco Leonardo K Ntoumi Francine Brasseur Philippe |
| author_sort | Ndounga Mathieu |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Congo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line and second-line anti-malarial drugs to treat uncomplicated <it>Plasmodium falciparum</it> malaria, respectively. The baseline efficacy of AS + AQ was evaluated from February to August 2005 in patients living in Brazzaville, the capital city of the Republic of Congo.</p> <p>Methods</p> <p>One hundred and ninety-seven patients (96 ≤5 years old and 101 >5 years old, including adults) were recruited in a non-randomized study, treated under supervision with AS + AQ, and were followed up for 28 days in accordance with the 2003 World Health Organization protocol. <it>Plasmodium falciparum</it> recrudescent isolates from day 7 to day 28 were compared to pretreatment isolates by polymerase chain reaction (PCR) to distinguish between re-infection and recrudescence.</p> <p>Results</p> <p>The overall efficacy of AS + AQ after PCR correction on day 28 was 94.4%. An adequate clinical and parasitological response was observed in 94.3% and 94.4% of children aged ≤5 years old and those aged >5 years old (including adults), respectively. The main reported adverse events were dizziness, vomiting, diarrhoea, pruritus, headache, anorexia, and abdominal pain.</p> <p>Conclusion</p> <p>This study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.</p> |
| first_indexed | 2024-12-11T00:05:34Z |
| format | Article |
| id | doaj.art-df8a7c0555624ac9b3c838ffbe2fd549 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-11T00:05:34Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-df8a7c0555624ac9b3c838ffbe2fd5492022-12-22T01:28:20ZengBMCMalaria Journal1475-28752013-02-011215310.1186/1475-2875-12-53Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in BrazzavilleNdounga MathieuMayengue Pembe IssamouCasimiro Prisca NadineLoumouamou DieudonnéBasco Leonardo KNtoumi FrancineBrasseur Philippe<p>Abstract</p> <p>Background</p> <p>Congo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line and second-line anti-malarial drugs to treat uncomplicated <it>Plasmodium falciparum</it> malaria, respectively. The baseline efficacy of AS + AQ was evaluated from February to August 2005 in patients living in Brazzaville, the capital city of the Republic of Congo.</p> <p>Methods</p> <p>One hundred and ninety-seven patients (96 ≤5 years old and 101 >5 years old, including adults) were recruited in a non-randomized study, treated under supervision with AS + AQ, and were followed up for 28 days in accordance with the 2003 World Health Organization protocol. <it>Plasmodium falciparum</it> recrudescent isolates from day 7 to day 28 were compared to pretreatment isolates by polymerase chain reaction (PCR) to distinguish between re-infection and recrudescence.</p> <p>Results</p> <p>The overall efficacy of AS + AQ after PCR correction on day 28 was 94.4%. An adequate clinical and parasitological response was observed in 94.3% and 94.4% of children aged ≤5 years old and those aged >5 years old (including adults), respectively. The main reported adverse events were dizziness, vomiting, diarrhoea, pruritus, headache, anorexia, and abdominal pain.</p> <p>Conclusion</p> <p>This study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.</p>http://www.malariajournal.com/content/12/1/53Drug resistanceArtemisininCombination therapyChloroquineDrug efficacyCongo-Brazzaville |
| spellingShingle | Ndounga Mathieu Mayengue Pembe Issamou Casimiro Prisca Nadine Loumouamou Dieudonné Basco Leonardo K Ntoumi Francine Brasseur Philippe Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville Malaria Journal Drug resistance Artemisinin Combination therapy Chloroquine Drug efficacy Congo-Brazzaville |
| title | Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville |
| title_full | Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville |
| title_fullStr | Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville |
| title_full_unstemmed | Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville |
| title_short | Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville |
| title_sort | artesunate amodiaquine efficacy in congolese children with acute uncomplicated falciparum malaria in brazzaville |
| topic | Drug resistance Artemisinin Combination therapy Chloroquine Drug efficacy Congo-Brazzaville |
| url | http://www.malariajournal.com/content/12/1/53 |
| work_keys_str_mv | AT ndoungamathieu artesunateamodiaquineefficacyincongolesechildrenwithacuteuncomplicatedfalciparummalariainbrazzaville AT mayenguepembeissamou artesunateamodiaquineefficacyincongolesechildrenwithacuteuncomplicatedfalciparummalariainbrazzaville AT casimiropriscanadine artesunateamodiaquineefficacyincongolesechildrenwithacuteuncomplicatedfalciparummalariainbrazzaville AT loumouamoudieudonne artesunateamodiaquineefficacyincongolesechildrenwithacuteuncomplicatedfalciparummalariainbrazzaville AT bascoleonardok artesunateamodiaquineefficacyincongolesechildrenwithacuteuncomplicatedfalciparummalariainbrazzaville AT ntoumifrancine artesunateamodiaquineefficacyincongolesechildrenwithacuteuncomplicatedfalciparummalariainbrazzaville AT brasseurphilippe artesunateamodiaquineefficacyincongolesechildrenwithacuteuncomplicatedfalciparummalariainbrazzaville |