Overview of renal osteodystrophy in Brazil: a cross-sectional study
Abstract Introduction: The epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross-sectional studies provide essential information to improve care and health policies. The Brazilian Registry of Bone Biopsy (REBRABO) is a prospective, nationalmulticenter cohort that inclu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2023-05-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002023005016501&lng=en&tlng=en |
| _version_ | 1797830878962909184 |
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| author | Cinthia E.M. Carbonara Noemi A.V. Roza Luciene M. dos Reis Aluízio B. Carvalho Vanda Jorgetti Rodrigo Bueno de Oliveira |
| author_facet | Cinthia E.M. Carbonara Noemi A.V. Roza Luciene M. dos Reis Aluízio B. Carvalho Vanda Jorgetti Rodrigo Bueno de Oliveira |
| author_sort | Cinthia E.M. Carbonara |
| collection | DOAJ |
| description | Abstract Introduction: The epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross-sectional studies provide essential information to improve care and health policies. The Brazilian Registry of Bone Biopsy (REBRABO) is a prospective, nationalmulticenter cohort that includes patients with chronic kidney disease (CKD) undergoing bone biopsy. REBRABO aims to provide clinical information on ROD. The main objective of this subanalysis was to describe the profile of ROD, including clinically relevant associations. Methods: From Aug/2015 to Dec/2021, 511 patients with CKD who performed bone biopsy were included in the REBRABO platform. Patients with no bone biopsy report (N = 40), GFR > 90 mL/min (N = 28), without asigned consent (N = 24), bone fragments inadequate for diagnosis (N = 23), bone biopsy indicated by a specialty other than nephrology (N = 6), and < 18 years old (N = 4) were excluded. Clinical-demographic data (e.g., age, sex, ethnicity, CKD etiology, dialysis vintage, comorbidities, symptoms, and complications related to ROD), laboratory (e.g., serum levels of total calcium, phosphate, parathormone, alkaline phosphatase, 25-hydroxyvitamin D, and hemoglobin), and ROD (e.g., histological diagnosis) were analyzed. Results: Data from 386 individuals were considered in this subanalysis of REBRABO. Mean age was 52 (42–60) years; 198 (51%) were male; 315 (82%) were on hemodialysis. Osteitis fibrosa (OF) [163 (42%)], adynamic bone disease (ABD) [96 (25%)] and mixed uremic osteodystrophy (MUO) [83 (21%)] were the most frequent diagnosis of ROD in our sample; 203 (54%) had the diagnosis of osteoporosis, 82 (56%) vascular calcification; 138 (36%) bone aluminum accumulation, and 137 (36%) iron intoxication; patients with high turnover were prone to present a higher frequency of symptoms. Conclusions: A high proportion of patients were diagnosed with OF and ABD, as well as osteoporosis, vascular calcification and clinical symptoms. |
| first_indexed | 2024-04-09T13:43:10Z |
| format | Article |
| id | doaj.art-df8a80dda1fc4fb4a5df5aab2fd26283 |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-04-09T13:43:10Z |
| publishDate | 2023-05-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-df8a80dda1fc4fb4a5df5aab2fd262832023-05-09T07:35:05ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392023-05-0110.1590/2175-8239-jbn-2022-0146enOverview of renal osteodystrophy in Brazil: a cross-sectional studyCinthia E.M. Carbonarahttps://orcid.org/0000-0003-2786-9200Noemi A.V. Rozahttps://orcid.org/0000-0003-3992-0368Luciene M. dos Reishttps://orcid.org/0000-0001-8476-6780Aluízio B. Carvalhohttps://orcid.org/0000-0001-5907-7764Vanda Jorgettihttps://orcid.org/0000-0002-4824-8879Rodrigo Bueno de Oliveirahttps://orcid.org/0000-0002-8273-6200Abstract Introduction: The epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross-sectional studies provide essential information to improve care and health policies. The Brazilian Registry of Bone Biopsy (REBRABO) is a prospective, nationalmulticenter cohort that includes patients with chronic kidney disease (CKD) undergoing bone biopsy. REBRABO aims to provide clinical information on ROD. The main objective of this subanalysis was to describe the profile of ROD, including clinically relevant associations. Methods: From Aug/2015 to Dec/2021, 511 patients with CKD who performed bone biopsy were included in the REBRABO platform. Patients with no bone biopsy report (N = 40), GFR > 90 mL/min (N = 28), without asigned consent (N = 24), bone fragments inadequate for diagnosis (N = 23), bone biopsy indicated by a specialty other than nephrology (N = 6), and < 18 years old (N = 4) were excluded. Clinical-demographic data (e.g., age, sex, ethnicity, CKD etiology, dialysis vintage, comorbidities, symptoms, and complications related to ROD), laboratory (e.g., serum levels of total calcium, phosphate, parathormone, alkaline phosphatase, 25-hydroxyvitamin D, and hemoglobin), and ROD (e.g., histological diagnosis) were analyzed. Results: Data from 386 individuals were considered in this subanalysis of REBRABO. Mean age was 52 (42–60) years; 198 (51%) were male; 315 (82%) were on hemodialysis. Osteitis fibrosa (OF) [163 (42%)], adynamic bone disease (ABD) [96 (25%)] and mixed uremic osteodystrophy (MUO) [83 (21%)] were the most frequent diagnosis of ROD in our sample; 203 (54%) had the diagnosis of osteoporosis, 82 (56%) vascular calcification; 138 (36%) bone aluminum accumulation, and 137 (36%) iron intoxication; patients with high turnover were prone to present a higher frequency of symptoms. Conclusions: A high proportion of patients were diagnosed with OF and ABD, as well as osteoporosis, vascular calcification and clinical symptoms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002023005016501&lng=en&tlng=enRenal Insufficiency, ChronicChronic Kidney Disease-Mineral and Bone Disorder |
| spellingShingle | Cinthia E.M. Carbonara Noemi A.V. Roza Luciene M. dos Reis Aluízio B. Carvalho Vanda Jorgetti Rodrigo Bueno de Oliveira Overview of renal osteodystrophy in Brazil: a cross-sectional study Brazilian Journal of Nephrology Renal Insufficiency, Chronic Chronic Kidney Disease-Mineral and Bone Disorder |
| title | Overview of renal osteodystrophy in Brazil: a cross-sectional study |
| title_full | Overview of renal osteodystrophy in Brazil: a cross-sectional study |
| title_fullStr | Overview of renal osteodystrophy in Brazil: a cross-sectional study |
| title_full_unstemmed | Overview of renal osteodystrophy in Brazil: a cross-sectional study |
| title_short | Overview of renal osteodystrophy in Brazil: a cross-sectional study |
| title_sort | overview of renal osteodystrophy in brazil a cross sectional study |
| topic | Renal Insufficiency, Chronic Chronic Kidney Disease-Mineral and Bone Disorder |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002023005016501&lng=en&tlng=en |
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