CO<sub>2</sub> Signaling through the Ptc2-Ssn3 Axis Governs Sustained Hyphal Development of <named-content content-type="genus-species">Candida albicans</named-content> by Reducing Ume6 Phosphorylation and Degradation

CO<sub>2</sub> Signaling through the Ptc2-Ssn3 Axis Governs Sustained Hyphal Development of <named-content content-type="genus-species">Candida albicans</named-content> by Reducing Ume6 Phosphorylation and Degradation

ABSTRACT Candida albicans is the most common cause of invasive fungal infections in humans. Its ability to sense and adapt to changing carbon dioxide levels is crucial for its pathogenesis. Carbon dioxide promotes hyphal development. The hypha-specific transcription factor Ume6 is rapidly degraded i...

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Bibliographic Details
Main Authors: Yang Lu, Chang Su, Shatarupa Ray, Yuncong Yuan, Haoping Liu
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
Candida albicans
Ssn3/Cdk8
Ume6
carbon dioxide signaling
hyphal development
Online Access:https://journals.asm.org/doi/10.1128/mBio.02320-18

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