Treatment aspirations and attitudes towards innovative medications among people living with HIV in 25 countries
Introduction The worldview in relation to patient care has shifted from conquering diseases to improving overall wellbeing and quality of life. We examined treatment aspirations among people living with HIV (PLHIV). Methods In all, 2389 PLHIV were surveyed in the 25-country 2019 Positive Perspectiv...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2020-07-01
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| Series: | Population Medicine |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/popmed/Treatment-Aspirations-and-Attitudes-Towards-Innovative-Medications-Among-People-Living,124781,0,2.html |
| _version_ | 1819087889909153792 |
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| author | Patricia de los Rios Chinyere Okoli Benjamin Young Brent Allan Erika Castellanos Garry Brough Anton Eremin Giulio M. Corbelli W. David Hardy Nicolas Van de Velde |
| author_facet | Patricia de los Rios Chinyere Okoli Benjamin Young Brent Allan Erika Castellanos Garry Brough Anton Eremin Giulio M. Corbelli W. David Hardy Nicolas Van de Velde |
| author_sort | Patricia de los Rios |
| collection | DOAJ |
| description | Introduction
The worldview in relation to patient care
has shifted from conquering diseases to improving overall
wellbeing and quality of life. We examined treatment
aspirations among people living with HIV (PLHIV).
Methods
In all, 2389 PLHIV were surveyed in the
25-country 2019 Positive Perspectives Study. Descriptive
and multivariable analyses were used to explore attitudes
towards treatment.
Results
Participants were from: Northern America (USA,
Canada), 21.8% (520/2389); Europe, 46.8% (1119/2389);
and other international regions, 31.4% (750/2389). Factors
associated with some level of dissatisfaction with HIV
medication among those otherwise fully satisfied with their
HIV management included being on a multi-tablet regimen
(AOR=2.76; 95% CI: 1.93–3.96), reporting polypharmacy
(AOR=2.10; 95% CI: 1.45–3.03), and experiencing side effects
from current HIV medication (AOR=2.12; 95% CI: 1.49–3.02).
Of seven improvements to HIV medications assessed, the
percentage ranking each attribute, as the first or second
most important, was: ‘reduced long-term impact on my body’
(46.7%); ‘longer-lasting medicine so I don’t have to take it
every day’ (43.1%); ‘fewer side effects’ (40.5%); ‘less HIV
medicine each day but just as effective’ (25.4%); ‘less chance
of affecting other medicines’ (21.6%); ‘no food restrictions/
requirements’ (14.0%); and ‘smaller pills’ (8.7%). Overall,
77.1% (1842/2389) believed ‘future advances in HIV
treatment will improve my overall wellbeing’, 72.2%
(1726/2389) were ‘open to taking an HIV treatment
composed of fewer medicines’, while 54.7% (1306/2389)
expressed openness towards longer-acting (non-daily)
HIV medication. Compared to those not fully satisfied with
either their HIV medication or management, those fully
satisfied with both reported significantly higher prevalence
of optimal treatment adherence (89.2% [372/417] vs 69.5%
[763/1098]) and optimal overall health (70.3% [293/417] vs
47.8% [525/1098]) (all p<0.001).
Conclusions
Many PLHIV perceived gaps in their care and
aspired for novel treatments. Providing flexible treatment
options can help patients across the spectrum of unmet
needs and improve health-related quality of life. |
| first_indexed | 2024-12-21T21:43:19Z |
| format | Article |
| id | doaj.art-df8b41ddf5b94c65807d0ad1e43d2a27 |
| institution | Directory Open Access Journal |
| issn | 2654-1459 |
| language | English |
| last_indexed | 2024-12-21T21:43:19Z |
| publishDate | 2020-07-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Population Medicine |
| spelling | doaj.art-df8b41ddf5b94c65807d0ad1e43d2a272022-12-21T18:49:18ZengEuropean PublishingPopulation Medicine2654-14592020-07-012July10.18332/popmed/124781124781Treatment aspirations and attitudes towards innovative medications among people living with HIV in 25 countriesPatricia de los Rios0Chinyere Okoli1Benjamin Young2Brent Allan3Erika Castellanos4Garry Brough5Anton Eremin6Giulio M. Corbelli7W. David Hardy8Nicolas Van de Velde9ViiV Healthcare, Research Triangle Park, United StatesViiV Healthcare, Brentford Middlesex, United KingdomViiV Healthcare, Research Triangle Park, United StatesInternational Council of AIDS Service Organizations (ICASO), Toronto, CanadaGlobal Action for Trans* Equality (GATE)Positively UK, London, United KingdomAIDS Center Foundation, Moscow, RussiaEuropean AIDS Treatment Group, Rome, ItalyDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, United StatesViiV Healthcare, Brentford Middlesex, United KingdomIntroduction The worldview in relation to patient care has shifted from conquering diseases to improving overall wellbeing and quality of life. We examined treatment aspirations among people living with HIV (PLHIV). Methods In all, 2389 PLHIV were surveyed in the 25-country 2019 Positive Perspectives Study. Descriptive and multivariable analyses were used to explore attitudes towards treatment. Results Participants were from: Northern America (USA, Canada), 21.8% (520/2389); Europe, 46.8% (1119/2389); and other international regions, 31.4% (750/2389). Factors associated with some level of dissatisfaction with HIV medication among those otherwise fully satisfied with their HIV management included being on a multi-tablet regimen (AOR=2.76; 95% CI: 1.93–3.96), reporting polypharmacy (AOR=2.10; 95% CI: 1.45–3.03), and experiencing side effects from current HIV medication (AOR=2.12; 95% CI: 1.49–3.02). Of seven improvements to HIV medications assessed, the percentage ranking each attribute, as the first or second most important, was: ‘reduced long-term impact on my body’ (46.7%); ‘longer-lasting medicine so I don’t have to take it every day’ (43.1%); ‘fewer side effects’ (40.5%); ‘less HIV medicine each day but just as effective’ (25.4%); ‘less chance of affecting other medicines’ (21.6%); ‘no food restrictions/ requirements’ (14.0%); and ‘smaller pills’ (8.7%). Overall, 77.1% (1842/2389) believed ‘future advances in HIV treatment will improve my overall wellbeing’, 72.2% (1726/2389) were ‘open to taking an HIV treatment composed of fewer medicines’, while 54.7% (1306/2389) expressed openness towards longer-acting (non-daily) HIV medication. Compared to those not fully satisfied with either their HIV medication or management, those fully satisfied with both reported significantly higher prevalence of optimal treatment adherence (89.2% [372/417] vs 69.5% [763/1098]) and optimal overall health (70.3% [293/417] vs 47.8% [525/1098]) (all p<0.001). Conclusions Many PLHIV perceived gaps in their care and aspired for novel treatments. Providing flexible treatment options can help patients across the spectrum of unmet needs and improve health-related quality of life.http://www.journalssystem.com/popmed/Treatment-Aspirations-and-Attitudes-Towards-Innovative-Medications-Among-People-Living,124781,0,2.htmlquality of lifestigmatreatment adherenceco-morbidities |
| spellingShingle | Patricia de los Rios Chinyere Okoli Benjamin Young Brent Allan Erika Castellanos Garry Brough Anton Eremin Giulio M. Corbelli W. David Hardy Nicolas Van de Velde Treatment aspirations and attitudes towards innovative medications among people living with HIV in 25 countries Population Medicine quality of life stigma treatment adherence co-morbidities |
| title | Treatment aspirations and attitudes towards innovative
medications among people living with HIV in 25 countries |
| title_full | Treatment aspirations and attitudes towards innovative
medications among people living with HIV in 25 countries |
| title_fullStr | Treatment aspirations and attitudes towards innovative
medications among people living with HIV in 25 countries |
| title_full_unstemmed | Treatment aspirations and attitudes towards innovative
medications among people living with HIV in 25 countries |
| title_short | Treatment aspirations and attitudes towards innovative
medications among people living with HIV in 25 countries |
| title_sort | treatment aspirations and attitudes towards innovative medications among people living with hiv in 25 countries |
| topic | quality of life stigma treatment adherence co-morbidities |
| url | http://www.journalssystem.com/popmed/Treatment-Aspirations-and-Attitudes-Towards-Innovative-Medications-Among-People-Living,124781,0,2.html |
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