Reciprocal regulation of actin filaments and cellular metabolism
For cells to adhere, migrate and proliferate, remodeling of the actin cytoskeleton is required. This process consumes a large amount of ATP while having an intimate connection with cellular metabolism. Signaling pathways that regulate energy homeostasis can also affect actin dynamics, whereas a vari...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S017193352200084X |
| _version_ | 1828121682845368320 |
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| author | Geyao Liu Jiayi Li Congying Wu |
| author_facet | Geyao Liu Jiayi Li Congying Wu |
| author_sort | Geyao Liu |
| collection | DOAJ |
| description | For cells to adhere, migrate and proliferate, remodeling of the actin cytoskeleton is required. This process consumes a large amount of ATP while having an intimate connection with cellular metabolism. Signaling pathways that regulate energy homeostasis can also affect actin dynamics, whereas a variety of actin binding proteins directly or indirectly interact with the anabolic and catabolic regulators in cells. Here, we discuss the inter-regulation between actin filaments and cellular metabolism, reviewing recent discoveries on key metabolic enzymes that respond to actin remodeling as well as historical findings on metabolic stress-induced cytoskeletal reorganization. We also address emerging techniques that would benefit the study of cytoskeletal dynamics and cellular metabolism in high spatial-temporal resolution. |
| first_indexed | 2024-04-11T14:22:41Z |
| format | Article |
| id | doaj.art-df8bde81f0bf4200b228e7c52cc3d818 |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-04-11T14:22:41Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-df8bde81f0bf4200b228e7c52cc3d8182022-12-22T04:19:00ZengElsevierEuropean Journal of Cell Biology0171-93352022-09-011014151281Reciprocal regulation of actin filaments and cellular metabolismGeyao Liu0Jiayi Li1Congying Wu2Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; International Cancer Institute, Peking University, Beijing 100191, China; Corresponding author at: Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.For cells to adhere, migrate and proliferate, remodeling of the actin cytoskeleton is required. This process consumes a large amount of ATP while having an intimate connection with cellular metabolism. Signaling pathways that regulate energy homeostasis can also affect actin dynamics, whereas a variety of actin binding proteins directly or indirectly interact with the anabolic and catabolic regulators in cells. Here, we discuss the inter-regulation between actin filaments and cellular metabolism, reviewing recent discoveries on key metabolic enzymes that respond to actin remodeling as well as historical findings on metabolic stress-induced cytoskeletal reorganization. We also address emerging techniques that would benefit the study of cytoskeletal dynamics and cellular metabolism in high spatial-temporal resolution.http://www.sciencedirect.com/science/article/pii/S017193352200084XActinStress fiberMetabolismGlycolysisCancer |
| spellingShingle | Geyao Liu Jiayi Li Congying Wu Reciprocal regulation of actin filaments and cellular metabolism European Journal of Cell Biology Actin Stress fiber Metabolism Glycolysis Cancer |
| title | Reciprocal regulation of actin filaments and cellular metabolism |
| title_full | Reciprocal regulation of actin filaments and cellular metabolism |
| title_fullStr | Reciprocal regulation of actin filaments and cellular metabolism |
| title_full_unstemmed | Reciprocal regulation of actin filaments and cellular metabolism |
| title_short | Reciprocal regulation of actin filaments and cellular metabolism |
| title_sort | reciprocal regulation of actin filaments and cellular metabolism |
| topic | Actin Stress fiber Metabolism Glycolysis Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S017193352200084X |
| work_keys_str_mv | AT geyaoliu reciprocalregulationofactinfilamentsandcellularmetabolism AT jiayili reciprocalregulationofactinfilamentsandcellularmetabolism AT congyingwu reciprocalregulationofactinfilamentsandcellularmetabolism |