Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study
Abstract Background Microcalcifications are suggested to be an indicator of thyroid malignancy, especially for papillary thyroid carcinoma (PTC), nonetheless, the association between macrocalcification and PTC is underexplored. Furthermore, screening methods like ultrasonography and ultrasound-guide...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-03016-7 |
| _version_ | 1797822842061979648 |
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| author | Mengyao Ye Shan Wu Qi Zhou Fang Wang Xiaojun Chen Xiaohua Gong Wenjun Wu |
| author_facet | Mengyao Ye Shan Wu Qi Zhou Fang Wang Xiaojun Chen Xiaohua Gong Wenjun Wu |
| author_sort | Mengyao Ye |
| collection | DOAJ |
| description | Abstract Background Microcalcifications are suggested to be an indicator of thyroid malignancy, especially for papillary thyroid carcinoma (PTC), nonetheless, the association between macrocalcification and PTC is underexplored. Furthermore, screening methods like ultrasonography and ultrasound-guided fine needle aspiration biopsy (US-FNAB) are limited in evaluating macro-calcified thyroid nodules. Thus, we aimed to investigate the relationship between macrocalcification and PTC. We also explored the diagnostic efficiency of US-FNAB and proto-Oncogene Proteins B-raf V600E (BRAF V600E) mutation in macro-calcified thyroid nodules evaluation. Methods A retrospective research of 2645 thyroid nodules from 2078 participants was performed and divided into three groups as non-, micro-, and macro-calcified for further PTC incidence comparison. Besides, a total of 100 macro-calcified thyroid nodules with both results of US-FNAB and BRAF V600E mutation were screened out for subsequent evaluation of diagnostic efficiency. Results Compared to non-calcification, macrocalcification showed a significantly higher incidence of PTC (31.5% vs. 23.2%, P<0.05). Additionally, when compared with a single US-FNAB, the combination of US-FNAB and BRAF V600E mutation showed better diagnostic efficiency in diagnosing macro-calcified thyroid nodule (area under the curve (AUC) 0.94 vs. 0.84, P=0.03), with a significantly higher sensitivity (100.0% vs. 67.2%, P<0.01) and a comparable standard of specificity (88.9% vs. 100.0%, P=0.13). Conclusions Occurrence of macrocalcification in thyroid nodules may suggest a high risk of PTC, and the combination of US-FNAB and BRAF V600E showed a greater value in identifying macro-calcified thyroid nodules, especially with significantly higher sensitivity. Trial registration The Ethics Committee of The First Affiliated Hospital of Wenzhou Medical University (2018-026). |
| first_indexed | 2024-03-13T10:15:15Z |
| format | Article |
| id | doaj.art-df8c4965bc6e49cebb777a2441738517 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-13T10:15:15Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-df8c4965bc6e49cebb777a24417385172023-05-21T11:18:02ZengBMCWorld Journal of Surgical Oncology1477-78192023-05-012111710.1186/s12957-023-03016-7Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective studyMengyao Ye0Shan Wu1Qi Zhou2Fang Wang3Xiaojun Chen4Xiaohua Gong5Wenjun Wu6Department of Endocrinology, Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineDepartment of Endocrinology, People’s Hospital of YuhuanDepartment of Endocrinology, First Affiliated Hospital of Wenzhou Medical UniversityDepartments of Pathology, First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Endocrinology, First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Endocrinology, First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Endocrinology, First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background Microcalcifications are suggested to be an indicator of thyroid malignancy, especially for papillary thyroid carcinoma (PTC), nonetheless, the association between macrocalcification and PTC is underexplored. Furthermore, screening methods like ultrasonography and ultrasound-guided fine needle aspiration biopsy (US-FNAB) are limited in evaluating macro-calcified thyroid nodules. Thus, we aimed to investigate the relationship between macrocalcification and PTC. We also explored the diagnostic efficiency of US-FNAB and proto-Oncogene Proteins B-raf V600E (BRAF V600E) mutation in macro-calcified thyroid nodules evaluation. Methods A retrospective research of 2645 thyroid nodules from 2078 participants was performed and divided into three groups as non-, micro-, and macro-calcified for further PTC incidence comparison. Besides, a total of 100 macro-calcified thyroid nodules with both results of US-FNAB and BRAF V600E mutation were screened out for subsequent evaluation of diagnostic efficiency. Results Compared to non-calcification, macrocalcification showed a significantly higher incidence of PTC (31.5% vs. 23.2%, P<0.05). Additionally, when compared with a single US-FNAB, the combination of US-FNAB and BRAF V600E mutation showed better diagnostic efficiency in diagnosing macro-calcified thyroid nodule (area under the curve (AUC) 0.94 vs. 0.84, P=0.03), with a significantly higher sensitivity (100.0% vs. 67.2%, P<0.01) and a comparable standard of specificity (88.9% vs. 100.0%, P=0.13). Conclusions Occurrence of macrocalcification in thyroid nodules may suggest a high risk of PTC, and the combination of US-FNAB and BRAF V600E showed a greater value in identifying macro-calcified thyroid nodules, especially with significantly higher sensitivity. Trial registration The Ethics Committee of The First Affiliated Hospital of Wenzhou Medical University (2018-026).https://doi.org/10.1186/s12957-023-03016-7Thyroid nodulePapillary thyroid carcinomaMacrocalcificationFine needle aspiration biopsyProto-Oncogene Proteins B-raf V600E |
| spellingShingle | Mengyao Ye Shan Wu Qi Zhou Fang Wang Xiaojun Chen Xiaohua Gong Wenjun Wu Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study World Journal of Surgical Oncology Thyroid nodule Papillary thyroid carcinoma Macrocalcification Fine needle aspiration biopsy Proto-Oncogene Proteins B-raf V600E |
| title | Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study |
| title_full | Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study |
| title_fullStr | Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study |
| title_full_unstemmed | Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study |
| title_short | Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study |
| title_sort | association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool retrospective study |
| topic | Thyroid nodule Papillary thyroid carcinoma Macrocalcification Fine needle aspiration biopsy Proto-Oncogene Proteins B-raf V600E |
| url | https://doi.org/10.1186/s12957-023-03016-7 |
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