Palladium-Catalyzed Benzodiazepines Synthesis
This review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C–H arylation, N-arylation, and the Buchwald–Hartwig reaction, depending on th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Catalysts |
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| Online Access: | https://www.mdpi.com/2073-4344/10/6/634 |
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| author | Michael S. Christodoulou Egle M. Beccalli Sabrina Giofrè |
| author_facet | Michael S. Christodoulou Egle M. Beccalli Sabrina Giofrè |
| author_sort | Michael S. Christodoulou |
| collection | DOAJ |
| description | This review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C–H arylation, N-arylation, and the Buchwald–Hartwig reaction, depending on the different substrates identified as halogenated starting materials (activated substrates) or unactivated unsaturated systems, which then exploit Pd(0)- or Pd(II)-catalytic species. In particular, the use of the domino reactions, as intra- or intermolecular processes, are reported as an efficient and eco-compatible tool to obtain differently functionalized benzodiazepines. Different domino reaction typologies are the carboamination, aminoarylation, aminoacethoxylation, aminohalogenation, and aminoazidation. |
| first_indexed | 2024-03-10T19:20:20Z |
| format | Article |
| id | doaj.art-df8c93e433634901ba8fcf412b771398 |
| institution | Directory Open Access Journal |
| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-10T19:20:20Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Catalysts |
| spelling | doaj.art-df8c93e433634901ba8fcf412b7713982023-11-20T03:03:50ZengMDPI AGCatalysts2073-43442020-06-0110663410.3390/catal10060634Palladium-Catalyzed Benzodiazepines SynthesisMichael S. Christodoulou0Egle M. Beccalli1Sabrina Giofrè2DISFARM, Sezione di Chimica Generale e Organica “A. Marchesini” Università degli Studi di Milano, via Venezian 21, 20133 Milano, ItalyDISFARM, Sezione di Chimica Generale e Organica “A. Marchesini” Università degli Studi di Milano, via Venezian 21, 20133 Milano, ItalyDISFARM, Sezione di Chimica Generale e Organica “A. Marchesini” Università degli Studi di Milano, via Venezian 21, 20133 Milano, ItalyThis review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C–H arylation, N-arylation, and the Buchwald–Hartwig reaction, depending on the different substrates identified as halogenated starting materials (activated substrates) or unactivated unsaturated systems, which then exploit Pd(0)- or Pd(II)-catalytic species. In particular, the use of the domino reactions, as intra- or intermolecular processes, are reported as an efficient and eco-compatible tool to obtain differently functionalized benzodiazepines. Different domino reaction typologies are the carboamination, aminoarylation, aminoacethoxylation, aminohalogenation, and aminoazidation.https://www.mdpi.com/2073-4344/10/6/634Pd-catalysisbenzodiazepinecyclizationdomino processintramolecular Buchwald–HartwigN-arylation |
| spellingShingle | Michael S. Christodoulou Egle M. Beccalli Sabrina Giofrè Palladium-Catalyzed Benzodiazepines Synthesis Catalysts Pd-catalysis benzodiazepine cyclization domino process intramolecular Buchwald–Hartwig N-arylation |
| title | Palladium-Catalyzed Benzodiazepines Synthesis |
| title_full | Palladium-Catalyzed Benzodiazepines Synthesis |
| title_fullStr | Palladium-Catalyzed Benzodiazepines Synthesis |
| title_full_unstemmed | Palladium-Catalyzed Benzodiazepines Synthesis |
| title_short | Palladium-Catalyzed Benzodiazepines Synthesis |
| title_sort | palladium catalyzed benzodiazepines synthesis |
| topic | Pd-catalysis benzodiazepine cyclization domino process intramolecular Buchwald–Hartwig N-arylation |
| url | https://www.mdpi.com/2073-4344/10/6/634 |
| work_keys_str_mv | AT michaelschristodoulou palladiumcatalyzedbenzodiazepinessynthesis AT eglembeccalli palladiumcatalyzedbenzodiazepinessynthesis AT sabrinagiofre palladiumcatalyzedbenzodiazepinessynthesis |