NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS
Silver nanoparticles (AgNPs) have important antimicrobial activity. These nanoparticles are present in several commercial products, leading to human and environmental exposure. This review presents a critical view of the toxic effects of Ag NPs on in vitro and in vivo biological models. It is notewo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000200206&lng=en&tlng=en |
| _version_ | 1818284878003699712 |
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| author | Nelson Durán Wallace R. Rolim Marcela Durán Wagner J. Fávaro Amedea B. Seabra |
| author_facet | Nelson Durán Wallace R. Rolim Marcela Durán Wagner J. Fávaro Amedea B. Seabra |
| author_sort | Nelson Durán |
| collection | DOAJ |
| description | Silver nanoparticles (AgNPs) have important antimicrobial activity. These nanoparticles are present in several commercial products, leading to human and environmental exposure. This review presents a critical view of the toxic effects of Ag NPs on in vitro and in vivo biological models. It is noteworthy that the toxicity of AgNPs is dependent on several parameters, such as the preparation mode of the colloidal suspension of the nanoparticles, their state of aggregation, the chemical nature of the nanoparticles, surface size, morphology, dose, cell type, nature of the living organism, among others. In general, low concentrations of AgNPs do not present significant toxicity in in vitro and in vivo assays, however with the increase of the concentration of AgNPs there is a significant increase of nanoparticle toxicity and its accumulation in diverse tissues/organs. It should be emphasized that in living organisms, exposure routes should be taken into account, such as ingestion and inhalation. At high concentrations, inhalation or ingestion of AgNPs can cause adverse effects and even lead to human death. In this context, the importance of further studies of the toxicity of AgNPs in several in vitro and in vivo models is emphasized. |
| first_indexed | 2024-12-13T00:59:48Z |
| format | Article |
| id | doaj.art-df8ca21a0f034bce9c28aef27b88c867 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-13T00:59:48Z |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-df8ca21a0f034bce9c28aef27b88c8672022-12-22T00:04:43ZengSociedade Brasileira de QuímicaQuímica Nova1678-706442220621310.21577/0100-4042.20170318S0100-40422019000200206NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOSNelson DuránWallace R. RolimMarcela DuránWagner J. FávaroAmedea B. SeabraSilver nanoparticles (AgNPs) have important antimicrobial activity. These nanoparticles are present in several commercial products, leading to human and environmental exposure. This review presents a critical view of the toxic effects of Ag NPs on in vitro and in vivo biological models. It is noteworthy that the toxicity of AgNPs is dependent on several parameters, such as the preparation mode of the colloidal suspension of the nanoparticles, their state of aggregation, the chemical nature of the nanoparticles, surface size, morphology, dose, cell type, nature of the living organism, among others. In general, low concentrations of AgNPs do not present significant toxicity in in vitro and in vivo assays, however with the increase of the concentration of AgNPs there is a significant increase of nanoparticle toxicity and its accumulation in diverse tissues/organs. It should be emphasized that in living organisms, exposure routes should be taken into account, such as ingestion and inhalation. At high concentrations, inhalation or ingestion of AgNPs can cause adverse effects and even lead to human death. In this context, the importance of further studies of the toxicity of AgNPs in several in vitro and in vivo models is emphasized.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000200206&lng=en&tlng=ensilver nanoparticlesnanotoxicityin vitro toxicityin vivo toxicity |
| spellingShingle | Nelson Durán Wallace R. Rolim Marcela Durán Wagner J. Fávaro Amedea B. Seabra NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS Química Nova silver nanoparticles nanotoxicity in vitro toxicity in vivo toxicity |
| title | NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
| title_full | NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
| title_fullStr | NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
| title_full_unstemmed | NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
| title_short | NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
| title_sort | nanotoxicologia de nanoparticulas de prata toxicidade em animais e humanos |
| topic | silver nanoparticles nanotoxicity in vitro toxicity in vivo toxicity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000200206&lng=en&tlng=en |
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