Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
To avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability of TRQ aerosols remain largely uninvestigated. This study aimed to investigat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.951613/full |
| _version_ | 1798041894344720384 |
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| author | Teng-Fei Chen Ling Song Yun-Hang Gao Han Li Jian-Liang Li Hong-Ping Hou Bo Peng Hui-Ying Wang Wen-Hao Cheng Zu-Guang Ye Ying-Fei Li Guang-Ping Zhang |
| author_facet | Teng-Fei Chen Ling Song Yun-Hang Gao Han Li Jian-Liang Li Hong-Ping Hou Bo Peng Hui-Ying Wang Wen-Hao Cheng Zu-Guang Ye Ying-Fei Li Guang-Ping Zhang |
| author_sort | Teng-Fei Chen |
| collection | DOAJ |
| description | To avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability of TRQ aerosols remain largely uninvestigated. This study aimed to investigate the size distribution of TRQ aerosols and to compare the pharmacokinetics and tissue distribution of two compounds from TRQ (baicalin and oroxyloside) after transnasal aerosol inhalation and intravenous administration. Furthermore, this study aimed to evaluate the efficacy of TRQ against lipopolysaccharide-induced lung inflammation. The Dv(50) and transmission of TRQ aerosols were 2.512 μm and 74.867%, respectively. The Cmax of baicalin and oroxyloside in rat plasma after inhalation was lower than that after intravenous injection. After inhalation, the area under the curve (AUC) of baicalin and oroxyloside in tissues (lung, bronchoalveolar lavage fluid, and trachea) was 7.9–115.3 and 9.5–16.0 times that observed after intravenous administration, respectively. Baicalin and oroxyloside maintained high concentrations 4 h after inhalation, but only 1 h after intravenous injection. The mean lung-to-plasma concentration ratios of baicalin and oroxyloside were 287.6 and 49.9 times higher than with intravenous administration. Inhaled TRQ achieved the same effect against lipopolysaccharide-induced lung inflammation in mice at doses of only 1/16–1/8 of those administered intravenously. The results indicate that TRQ inhalation is a promising alternative to intravenous injections for the treatment of respiratory infection. |
| first_indexed | 2024-04-11T22:27:57Z |
| format | Article |
| id | doaj.art-df8cfe4eea4b4bd8bc43edf7b32a52d4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T22:27:57Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-df8cfe4eea4b4bd8bc43edf7b32a52d42022-12-22T03:59:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.951613951613Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of TanreqingTeng-Fei Chen0Ling Song1Yun-Hang Gao2Han Li3Jian-Liang Li4Hong-Ping Hou5Bo Peng6Hui-Ying Wang7Wen-Hao Cheng8Zu-Guang Ye9Ying-Fei Li10Guang-Ping Zhang11Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, ChinaTo avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability of TRQ aerosols remain largely uninvestigated. This study aimed to investigate the size distribution of TRQ aerosols and to compare the pharmacokinetics and tissue distribution of two compounds from TRQ (baicalin and oroxyloside) after transnasal aerosol inhalation and intravenous administration. Furthermore, this study aimed to evaluate the efficacy of TRQ against lipopolysaccharide-induced lung inflammation. The Dv(50) and transmission of TRQ aerosols were 2.512 μm and 74.867%, respectively. The Cmax of baicalin and oroxyloside in rat plasma after inhalation was lower than that after intravenous injection. After inhalation, the area under the curve (AUC) of baicalin and oroxyloside in tissues (lung, bronchoalveolar lavage fluid, and trachea) was 7.9–115.3 and 9.5–16.0 times that observed after intravenous administration, respectively. Baicalin and oroxyloside maintained high concentrations 4 h after inhalation, but only 1 h after intravenous injection. The mean lung-to-plasma concentration ratios of baicalin and oroxyloside were 287.6 and 49.9 times higher than with intravenous administration. Inhaled TRQ achieved the same effect against lipopolysaccharide-induced lung inflammation in mice at doses of only 1/16–1/8 of those administered intravenously. The results indicate that TRQ inhalation is a promising alternative to intravenous injections for the treatment of respiratory infection.https://www.frontiersin.org/articles/10.3389/fphar.2022.951613/fullbaicalinlungoroxylosidepharmacokineticsTanreqingtransnasal aerosol inhalation |
| spellingShingle | Teng-Fei Chen Ling Song Yun-Hang Gao Han Li Jian-Liang Li Hong-Ping Hou Bo Peng Hui-Ying Wang Wen-Hao Cheng Zu-Guang Ye Ying-Fei Li Guang-Ping Zhang Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing Frontiers in Pharmacology baicalin lung oroxyloside pharmacokinetics Tanreqing transnasal aerosol inhalation |
| title | Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing |
| title_full | Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing |
| title_fullStr | Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing |
| title_full_unstemmed | Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing |
| title_short | Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing |
| title_sort | pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of tanreqing |
| topic | baicalin lung oroxyloside pharmacokinetics Tanreqing transnasal aerosol inhalation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.951613/full |
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