IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis

Abstract Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Martyna Scibiorek, Nontobeko Mthembu, Sandisiwe Mangali, Amkele Ngomti, Paul Ikwegbue, Frank Brombacher, Sabelo Hadebe
Formato: Artículo
Lenguaje:English
Publicado: Nature Portfolio 2023-01-01
Colección:Scientific Reports
Acceso en línea:https://doi.org/10.1038/s41598-022-26637-6