IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis

Abstract Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the dis...

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Detalles Bibliográficos
Main Authors: Martyna Scibiorek, Nontobeko Mthembu, Sandisiwe Mangali, Amkele Ngomti, Paul Ikwegbue, Frank Brombacher, Sabelo Hadebe
Formato: Artigo
Idioma:English
Publicado: Nature Portfolio 2023-01-01
Series:Scientific Reports
Acceso en liña:https://doi.org/10.1038/s41598-022-26637-6