IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis

Abstract Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the dis...

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Bibliografske podrobnosti
Main Authors: Martyna Scibiorek, Nontobeko Mthembu, Sandisiwe Mangali, Amkele Ngomti, Paul Ikwegbue, Frank Brombacher, Sabelo Hadebe
Format: Article
Jezik:English
Izdano: Nature Portfolio 2023-01-01
Serija:Scientific Reports
Online dostop:https://doi.org/10.1038/s41598-022-26637-6