Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin

Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin

<p>Abstract</p> <p>Background</p> <p>Influenza A virus non-structural protein 1 (NS1) is a virulence factor, which is targeted into the cell cytoplasm, nucleus and nucleolus. NS1 is a multi-functional protein that inhibits host cell pre-mRNA processing and counteracts h...

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Bibliographic Details
Main Authors: Melén Krister, Tynell Janne, Fagerlund Riku, Roussel Pascal, Hernandez-Verdun Danièle, Julkunen Ilkka
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Virology Journal
Subjects:
Influenza A virus
NS1 protein
NoLS
Nucleolus
Nucleolin
B23
Fibrillarin
Online Access:http://www.virologyj.com/content/9/1/167

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