LncRNA PVT1 regulates atrial fibrosis via miR-128-3p-SP1-TGF-β1-Smad axis in atrial fibrillation

LncRNA PVT1 regulates atrial fibrosis via miR-128-3p-SP1-TGF-β1-Smad axis in atrial fibrillation

Abstract Background Long non-coding RNAs (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been shown to be associated with liver fibrosis. Nevertheless, the role of PVT1 in atrial fibrosis remains undefined. This study aims to elucidate the pathophysiological role of lncRNA PVT1 in the regul...

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Bibliographic Details
Main Authors: Feng Cao, Zhe Li, Wen-mao Ding, Ling Yan, Qing-yan Zhao
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Medicine
Subjects:
PVT1
miR-128-3p
Sp1
TGF-β1/Smad signaling
Atrial fibrosis
Atrial fibrillation
Online Access:http://link.springer.com/article/10.1186/s10020-019-0074-5

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