Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17329-8 |
| _version_ | 1818856255455756288 |
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| author | Kenneth C. P. Cheung Silvia Fanti Claudio Mauro Guosu Wang Anitha S. Nair Hongmei Fu Silvia Angeletti Silvia Spoto Marta Fogolari Francesco Romano Dunja Aksentijevic Weiwei Liu Baiying Li Lixin Cheng Liwen Jiang Juho Vuononvirta Thanushiyan R. Poobalasingam David M. Smith Massimo Ciccozzi Egle Solito Federica M. Marelli-Berg |
| author_facet | Kenneth C. P. Cheung Silvia Fanti Claudio Mauro Guosu Wang Anitha S. Nair Hongmei Fu Silvia Angeletti Silvia Spoto Marta Fogolari Francesco Romano Dunja Aksentijevic Weiwei Liu Baiying Li Lixin Cheng Liwen Jiang Juho Vuononvirta Thanushiyan R. Poobalasingam David M. Smith Massimo Ciccozzi Egle Solito Federica M. Marelli-Berg |
| author_sort | Kenneth C. P. Cheung |
| collection | DOAJ |
| description | The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism. |
| first_indexed | 2024-12-19T08:21:36Z |
| format | Article |
| id | doaj.art-df928ac93a0a4597a8951f70e8733d1b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:21:36Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-df928ac93a0a4597a8951f70e8733d1b2022-12-21T20:29:23ZengNature PortfolioNature Communications2041-17232020-07-0111111810.1038/s41467-020-17329-8Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogrammingKenneth C. P. Cheung0Silvia Fanti1Claudio Mauro2Guosu Wang3Anitha S. Nair4Hongmei Fu5Silvia Angeletti6Silvia Spoto7Marta Fogolari8Francesco Romano9Dunja Aksentijevic10Weiwei Liu11Baiying Li12Lixin Cheng13Liwen Jiang14Juho Vuononvirta15Thanushiyan R. Poobalasingam16David M. Smith17Massimo Ciccozzi18Egle Solito19Federica M. Marelli-Berg20William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonUnit of Clinical Laboratory Science, University Campus Bio-Medico of RomeInternal Medicine Department, University campus Bio-Medico of RomeUnit of Clinical Laboratory Science, University Campus Bio-Medico of RomeUnit of Clinical Laboratory Science, University Campus Bio-Medico of RomeSchool of Biological and Chemical Sciences, Queen Mary University of LondonDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South ChinaSchool of Life Sciences, Centre for Cell & Developmental Biology and Partner State Key Laboratory of Agrobiotechnology, The Chinese University of Hong KongSchool of Life Sciences, Centre for Cell & Developmental Biology and Partner State Key Laboratory of Agrobiotechnology, The Chinese University of Hong KongSchool of Life Sciences, Centre for Cell & Developmental Biology and Partner State Key Laboratory of Agrobiotechnology, The Chinese University of Hong KongWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonAstraZeneca R&D, Cambridge Science ParkUnit of Medical Statistic and Molecular Epidemiology, University Campus Bio-Medico of RomeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonThe mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.https://doi.org/10.1038/s41467-020-17329-8 |
| spellingShingle | Kenneth C. P. Cheung Silvia Fanti Claudio Mauro Guosu Wang Anitha S. Nair Hongmei Fu Silvia Angeletti Silvia Spoto Marta Fogolari Francesco Romano Dunja Aksentijevic Weiwei Liu Baiying Li Lixin Cheng Liwen Jiang Juho Vuononvirta Thanushiyan R. Poobalasingam David M. Smith Massimo Ciccozzi Egle Solito Federica M. Marelli-Berg Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming Nature Communications |
| title | Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming |
| title_full | Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming |
| title_fullStr | Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming |
| title_full_unstemmed | Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming |
| title_short | Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming |
| title_sort | preservation of microvascular barrier function requires cd31 receptor induced metabolic reprogramming |
| url | https://doi.org/10.1038/s41467-020-17329-8 |
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