Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature

Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature

Therapy resistance represents an unmet challenge in the treatment of medulloblastoma. Accordingly, the identification of targets that mark drug-resistant cell populations, or drive the proliferation of resistant cells, may improve treatment strategies. To address this, we undertook a targeted approa...

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Bibliographic Details
Main Authors: Louisa Taylor, Philippa K. Wade, James E. C. Johnson, Macha Aldighieri, Sonia Morlando, Gianpiero Di Leva, Ian D. Kerr, Beth Coyle
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
medulloblastoma
drug resistance
cancer cell invasion
ABC transporter
YB-1
vincristine
Online Access:https://www.mdpi.com/2072-6694/15/4/1086

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