Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes
Objective: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors can generate β-like gut cells. Methods: We used Ng...
Main Authors: | Takumi Kitamoto, Yun-Kyoung Lee, Nishat Sultana, Hitoshi Watanabe, Wendy M. McKimpson, Wen Du, Jason Fan, Bryan Diaz, Hua V. Lin, Rudolph L. Leibel, Sandro Belvedere, Domenico Accili |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-12-01
|
Series: | Molecular Metabolism |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877822001934 |
Similar Items
-
Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice
by: Yun-Kyoung Lee, et al.
Published: (2022-12-01) -
Role of FoxO Proteins in Cellular Response to Antitumor Agents
by: Giovanni Luca Beretta, et al.
Published: (2019-01-01) -
Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway
by: Cuilin Zhang, et al.
Published: (2019-09-01) -
FoxO1 is a negative regulator of neointimal hyperplasia in a rat model of patch angioplasty
by: Peng Sun, et al.
Published: (2023-09-01) -
FoxK1 associated gene regulatory network in hepatic insulin action and its relationship to FoxO1 and insulin receptor mediated transcriptional regulation
by: Prasanna K.R. Allu, et al.
Published: (2023-12-01)