Structural basis of peptide recognition and activation of endothelin receptors

Endothelin receptors (ETAR and ETBR) are critical for vasoregulation and are targets for cardiovascular diseases treatment. Here, the authors offer a structural basis for peptide recognition selectivity and activation of both endothelin receptors.

Bibliographic Details
Main Authors: Yujie Ji, Jia Duan, Qingning Yuan, Xinheng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36998-9
Description
Summary:Endothelin receptors (ETAR and ETBR) are critical for vasoregulation and are targets for cardiovascular diseases treatment. Here, the authors offer a structural basis for peptide recognition selectivity and activation of both endothelin receptors.
ISSN:2041-1723