In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release
Since the number of antibiotic-resistant bacterial infections is growing and cases are getting worse every year, the search for new alternative bactericidal wound dressing treatments is becoming crucial. Within this context, the use of polysaccharides from plants and seeds in innovative biopolymer t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/22/4983 |
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| author | Adriana Freire Lubambo Ney Mattoso Lucy Ono Gisele Gomes da Luz Bruno Gavinho Andressa Amado Martin Maria Rita Sierakowski Cyro Ketzer Saul |
| author_facet | Adriana Freire Lubambo Ney Mattoso Lucy Ono Gisele Gomes da Luz Bruno Gavinho Andressa Amado Martin Maria Rita Sierakowski Cyro Ketzer Saul |
| author_sort | Adriana Freire Lubambo |
| collection | DOAJ |
| description | Since the number of antibiotic-resistant bacterial infections is growing and cases are getting worse every year, the search for new alternative bactericidal wound dressing treatments is becoming crucial. Within this context, the use of polysaccharides from plants and seeds in innovative biopolymer technologies is of key importance. In this work, bio-nano-composite guar gum/polyvinyl alcohol (PVOH) membranes loaded with aluminum-doped zinc oxide nanoparticles were produced via electrospinning. Citric acid was added to the mixture to increase spinnability. However, depending on the pH, zinc oxide nanoparticles are partially dissociated, decreasing their bactericidal efficiency. Thus, a second successful alkaline thermo-chemical regrowth step was added to the process to treat the obtained fibers. This alkaline thermo-chemical treatment reconstituted both the nanoparticles and their bactericidal properties. The <i>Staphylococcus aureus</i> antibacterial assay results show that the membranes obtained after the alkaline thermo-chemical treatment presented a 57% increase in growth inhibition. |
| first_indexed | 2024-03-09T18:03:26Z |
| format | Article |
| id | doaj.art-df9af7b2f9f64c05be339d37540fc0ad |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T18:03:26Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-df9af7b2f9f64c05be339d37540fc0ad2023-11-24T09:44:12ZengMDPI AGPolymers2073-43602022-11-011422498310.3390/polym14224983In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal ReleaseAdriana Freire Lubambo0Ney Mattoso1Lucy Ono2Gisele Gomes da Luz3Bruno Gavinho4Andressa Amado Martin5Maria Rita Sierakowski6Cyro Ketzer Saul7Department of Physics, LITS, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitiba P.O. Box 19044, PR, BrazilDepartment of Physics, LITS, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitiba P.O. Box 19044, PR, BrazilDepartment of Basic Pathology, Yasuyoshi Hayashi Microbiology Laboratory, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitiba P.O. Box 19031, PR, BrazilDepartment of Basic Pathology, Yasuyoshi Hayashi Microbiology Laboratory, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitiba P.O. Box 19031, PR, BrazilDepartment of Basic Pathology, Yasuyoshi Hayashi Microbiology Laboratory, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitiba P.O. Box 19031, PR, BrazilDepartment of Chemistry, Biopol Laboratory, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitba P.O. Box 1908, PR, BrazilDepartment of Chemistry, Biopol Laboratory, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitba P.O. Box 1908, PR, BrazilDepartment of Physics, LITS, Universidade Federal do Paraná-UFPR, Centro Politécnico, Curitiba P.O. Box 19044, PR, BrazilSince the number of antibiotic-resistant bacterial infections is growing and cases are getting worse every year, the search for new alternative bactericidal wound dressing treatments is becoming crucial. Within this context, the use of polysaccharides from plants and seeds in innovative biopolymer technologies is of key importance. In this work, bio-nano-composite guar gum/polyvinyl alcohol (PVOH) membranes loaded with aluminum-doped zinc oxide nanoparticles were produced via electrospinning. Citric acid was added to the mixture to increase spinnability. However, depending on the pH, zinc oxide nanoparticles are partially dissociated, decreasing their bactericidal efficiency. Thus, a second successful alkaline thermo-chemical regrowth step was added to the process to treat the obtained fibers. This alkaline thermo-chemical treatment reconstituted both the nanoparticles and their bactericidal properties. The <i>Staphylococcus aureus</i> antibacterial assay results show that the membranes obtained after the alkaline thermo-chemical treatment presented a 57% increase in growth inhibition.https://www.mdpi.com/2073-4360/14/22/4983AZO-Npguar gumnanoparticle regrowthcomposite membrane electrospun |
| spellingShingle | Adriana Freire Lubambo Ney Mattoso Lucy Ono Gisele Gomes da Luz Bruno Gavinho Andressa Amado Martin Maria Rita Sierakowski Cyro Ketzer Saul In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release Polymers AZO-Np guar gum nanoparticle regrowth composite membrane electrospun |
| title | In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release |
| title_full | In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release |
| title_fullStr | In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release |
| title_full_unstemmed | In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release |
| title_short | In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release |
| title_sort | in situ synthesis of azo np in guar gum pvoh composite fiber mats for potential bactericidal release |
| topic | AZO-Np guar gum nanoparticle regrowth composite membrane electrospun |
| url | https://www.mdpi.com/2073-4360/14/22/4983 |
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