Moderate Increase of Indoxyl Sulfate Promotes Monocyte Transition into Profibrotic Macrophages.

Moderate Increase of Indoxyl Sulfate Promotes Monocyte Transition into Profibrotic Macrophages.

OBJECTIVE:The uremic toxin Indoxyl-3-sulphate (IS), a ligand of Aryl hydrocarbon Receptor (AhR), raises in blood during early renal dysfunction as a consequence of tubular damage, which may be present even when eGFR is normal or only moderately reduced, and promotes cardiovascular damage and monocyt...

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Main Authors: Chiara Barisione, Silvano Garibaldi, Anna Lisa Furfaro, Mariapaola Nitti, Daniela Palmieri, Mario Passalacqua, Anna Garuti, Daniela Verzola, Alessia Parodi, Pietro Ameri, Paola Altieri, Patrizia Fabbi, Pier Francesco Ferrar, Claudio Brunelli, Violeta Arsenescu, Manrico Balbi, Domenico Palombo, Giorgio Ghigliotti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4771744?pdf=render

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