Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention
Prostate cancer (PCa) is a multifactorial disease with an unclear etiology. Due to its high prevalence, long latency, and slow progression, PCa is an ideal target for chemoprevention strategies. Many research studies have highlighted the positive effects of natural flavonoids on chronic diseases, in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/4/1010 |
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| author | Simona Izzo Valeria Naponelli Saverio Bettuzzi |
| author_facet | Simona Izzo Valeria Naponelli Saverio Bettuzzi |
| author_sort | Simona Izzo |
| collection | DOAJ |
| description | Prostate cancer (PCa) is a multifactorial disease with an unclear etiology. Due to its high prevalence, long latency, and slow progression, PCa is an ideal target for chemoprevention strategies. Many research studies have highlighted the positive effects of natural flavonoids on chronic diseases, including PCa. Different classes of dietary flavonoids exhibit anti-oxidative, anti-inflammatory, anti-mutagenic, anti-aging, cardioprotective, anti-viral/bacterial and anti-carcinogenic properties. We overviewed the most recent evidence of the antitumoral effects exerted by dietary flavonoids, with a special focus on their epigenetic action in PCa. Epigenetic alterations have been identified as key initiating events in several kinds of cancer. Many dietary flavonoids have been found to reverse DNA aberrations that promote neoplastic transformation, particularly for PCa. The epigenetic targets of the actions of flavonoids include oncogenes and tumor suppressor genes, indirectly controlled through the regulation of epigenetic enzymes such as DNA methyltransferase (DNMT), histone acetyltransferase (HAT), and histone deacetylase (HDAC). In addition, flavonoids were found capable of restoring miRNA and lncRNA expression that is altered during diseases. The optimization of the use of flavonoids as natural epigenetic modulators for chemoprevention and as a possible treatment of PCa and other kinds of cancers could represent a promising and valid strategy to inhibit carcinogenesis and fight cancer. |
| first_indexed | 2024-03-10T20:39:17Z |
| format | Article |
| id | doaj.art-df9b2a463cd5457584ec90bde45e31be |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:39:17Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-df9b2a463cd5457584ec90bde45e31be2023-11-19T20:50:36ZengMDPI AGNutrients2072-66432020-04-01124101010.3390/nu12041010Flavonoids as Epigenetic Modulators for Prostate Cancer PreventionSimona Izzo0Valeria Naponelli1Saverio Bettuzzi2Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, Via Volturno 39, 43125 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, Via Volturno 39, 43125 Parma, ItalyProstate cancer (PCa) is a multifactorial disease with an unclear etiology. Due to its high prevalence, long latency, and slow progression, PCa is an ideal target for chemoprevention strategies. Many research studies have highlighted the positive effects of natural flavonoids on chronic diseases, including PCa. Different classes of dietary flavonoids exhibit anti-oxidative, anti-inflammatory, anti-mutagenic, anti-aging, cardioprotective, anti-viral/bacterial and anti-carcinogenic properties. We overviewed the most recent evidence of the antitumoral effects exerted by dietary flavonoids, with a special focus on their epigenetic action in PCa. Epigenetic alterations have been identified as key initiating events in several kinds of cancer. Many dietary flavonoids have been found to reverse DNA aberrations that promote neoplastic transformation, particularly for PCa. The epigenetic targets of the actions of flavonoids include oncogenes and tumor suppressor genes, indirectly controlled through the regulation of epigenetic enzymes such as DNA methyltransferase (DNMT), histone acetyltransferase (HAT), and histone deacetylase (HDAC). In addition, flavonoids were found capable of restoring miRNA and lncRNA expression that is altered during diseases. The optimization of the use of flavonoids as natural epigenetic modulators for chemoprevention and as a possible treatment of PCa and other kinds of cancers could represent a promising and valid strategy to inhibit carcinogenesis and fight cancer.https://www.mdpi.com/2072-6643/12/4/1010prostate cancerflavonoidsepigenetic regulationmiRNAsgreen tea catechinsnatural compounds |
| spellingShingle | Simona Izzo Valeria Naponelli Saverio Bettuzzi Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention Nutrients prostate cancer flavonoids epigenetic regulation miRNAs green tea catechins natural compounds |
| title | Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention |
| title_full | Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention |
| title_fullStr | Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention |
| title_full_unstemmed | Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention |
| title_short | Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention |
| title_sort | flavonoids as epigenetic modulators for prostate cancer prevention |
| topic | prostate cancer flavonoids epigenetic regulation miRNAs green tea catechins natural compounds |
| url | https://www.mdpi.com/2072-6643/12/4/1010 |
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