The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract

Rebamipide is a cytoprotесtive drug that stimulates the generation of endogenous prostaglandins in the gastric and small intestinal mucosa and accelerates the healing of erosions and ulcers caused by Helicobacter pylori infection and NSAID administration. The major properties of rebamipide include s...

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Main Authors: E P Yakovenko, N A Agafonova, A N Ivanov, A V Yakovenko, M A Aldiyarova, T V Volosheinikova, Yu V Grigoryeva, I P Soluyanova
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2016-04-01
Series:Терапевтический архив
Subjects:
Online Access:https://ter-arkhiv.ru/0040-3660/article/viewFile/31991/pdf
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author E P Yakovenko
N A Agafonova
A N Ivanov
A V Yakovenko
M A Aldiyarova
T V Volosheinikova
Yu V Grigoryeva
I P Soluyanova
author_facet E P Yakovenko
N A Agafonova
A N Ivanov
A V Yakovenko
M A Aldiyarova
T V Volosheinikova
Yu V Grigoryeva
I P Soluyanova
author_sort E P Yakovenko
collection DOAJ
description Rebamipide is a cytoprotесtive drug that stimulates the generation of endogenous prostaglandins in the gastric and small intestinal mucosa and accelerates the healing of erosions and ulcers caused by Helicobacter pylori infection and NSAID administration. The major properties of rebamipide include stimulation of prostaglandins and synthesis of muсus glycoproteins, inhibition of reactive oxygen species, inflammatory cytokines, and chemokines, and suppression of neutrophil activation. This paper shows the ability of rebamipide to enhance the efficiency of therapy for Helicobacter pylori-induced infection, to reduce inflammation, including that after infection eradication, to accelerate ulcer healing, and to prevent the progression of preneoplastic lesions.
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spelling doaj.art-df9b6ab9da724d8e9885b4eb4f56793c2022-12-21T18:51:25Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422016-04-01884889229007The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tractE P YakovenkoN A AgafonovaA N IvanovA V YakovenkoM A AldiyarovaT V VolosheinikovaYu V GrigoryevaI P SoluyanovaRebamipide is a cytoprotесtive drug that stimulates the generation of endogenous prostaglandins in the gastric and small intestinal mucosa and accelerates the healing of erosions and ulcers caused by Helicobacter pylori infection and NSAID administration. The major properties of rebamipide include stimulation of prostaglandins and synthesis of muсus glycoproteins, inhibition of reactive oxygen species, inflammatory cytokines, and chemokines, and suppression of neutrophil activation. This paper shows the ability of rebamipide to enhance the efficiency of therapy for Helicobacter pylori-induced infection, to reduce inflammation, including that after infection eradication, to accelerate ulcer healing, and to prevent the progression of preneoplastic lesions.https://ter-arkhiv.ru/0040-3660/article/viewFile/31991/pdfgastric cytoprotectiongastric ulcerprostaglandinscytokineshelicobacter pylorihelicobacter pylori-associated gastropathyenteropathy
spellingShingle E P Yakovenko
N A Agafonova
A N Ivanov
A V Yakovenko
M A Aldiyarova
T V Volosheinikova
Yu V Grigoryeva
I P Soluyanova
The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract
Терапевтический архив
gastric cytoprotection
gastric ulcer
prostaglandins
cytokines
helicobacter pylori
helicobacter pylori-associated gastropathy
enteropathy
title The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract
title_full The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract
title_fullStr The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract
title_full_unstemmed The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract
title_short The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract
title_sort cytoprotective drug rebamipide in therapy for inflammatory and erosive ulcerative lesions of the gastrointestinal tract
topic gastric cytoprotection
gastric ulcer
prostaglandins
cytokines
helicobacter pylori
helicobacter pylori-associated gastropathy
enteropathy
url https://ter-arkhiv.ru/0040-3660/article/viewFile/31991/pdf
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