The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract
Rebamipide is a cytoprotесtive drug that stimulates the generation of endogenous prostaglandins in the gastric and small intestinal mucosa and accelerates the healing of erosions and ulcers caused by Helicobacter pylori infection and NSAID administration. The major properties of rebamipide include s...
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Format: | Article |
Language: | Russian |
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"Consilium Medicum" Publishing house
2016-04-01
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Series: | Терапевтический архив |
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Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/31991/pdf |
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author | E P Yakovenko N A Agafonova A N Ivanov A V Yakovenko M A Aldiyarova T V Volosheinikova Yu V Grigoryeva I P Soluyanova |
author_facet | E P Yakovenko N A Agafonova A N Ivanov A V Yakovenko M A Aldiyarova T V Volosheinikova Yu V Grigoryeva I P Soluyanova |
author_sort | E P Yakovenko |
collection | DOAJ |
description | Rebamipide is a cytoprotесtive drug that stimulates the generation of endogenous prostaglandins in the gastric and small intestinal mucosa and accelerates the healing of erosions and ulcers caused by Helicobacter pylori infection and NSAID administration. The major properties of rebamipide include stimulation of prostaglandins and synthesis of muсus glycoproteins, inhibition of reactive oxygen species, inflammatory cytokines, and chemokines, and suppression of neutrophil activation. This paper shows the ability of rebamipide to enhance the efficiency of therapy for Helicobacter pylori-induced infection, to reduce inflammation, including that after infection eradication, to accelerate ulcer healing, and to prevent the progression of preneoplastic lesions. |
first_indexed | 2024-12-21T20:24:33Z |
format | Article |
id | doaj.art-df9b6ab9da724d8e9885b4eb4f56793c |
institution | Directory Open Access Journal |
issn | 0040-3660 2309-5342 |
language | Russian |
last_indexed | 2024-12-21T20:24:33Z |
publishDate | 2016-04-01 |
publisher | "Consilium Medicum" Publishing house |
record_format | Article |
series | Терапевтический архив |
spelling | doaj.art-df9b6ab9da724d8e9885b4eb4f56793c2022-12-21T18:51:25Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422016-04-01884889229007The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tractE P YakovenkoN A AgafonovaA N IvanovA V YakovenkoM A AldiyarovaT V VolosheinikovaYu V GrigoryevaI P SoluyanovaRebamipide is a cytoprotесtive drug that stimulates the generation of endogenous prostaglandins in the gastric and small intestinal mucosa and accelerates the healing of erosions and ulcers caused by Helicobacter pylori infection and NSAID administration. The major properties of rebamipide include stimulation of prostaglandins and synthesis of muсus glycoproteins, inhibition of reactive oxygen species, inflammatory cytokines, and chemokines, and suppression of neutrophil activation. This paper shows the ability of rebamipide to enhance the efficiency of therapy for Helicobacter pylori-induced infection, to reduce inflammation, including that after infection eradication, to accelerate ulcer healing, and to prevent the progression of preneoplastic lesions.https://ter-arkhiv.ru/0040-3660/article/viewFile/31991/pdfgastric cytoprotectiongastric ulcerprostaglandinscytokineshelicobacter pylorihelicobacter pylori-associated gastropathyenteropathy |
spellingShingle | E P Yakovenko N A Agafonova A N Ivanov A V Yakovenko M A Aldiyarova T V Volosheinikova Yu V Grigoryeva I P Soluyanova The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract Терапевтический архив gastric cytoprotection gastric ulcer prostaglandins cytokines helicobacter pylori helicobacter pylori-associated gastropathy enteropathy |
title | The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract |
title_full | The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract |
title_fullStr | The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract |
title_full_unstemmed | The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract |
title_short | The cytoprotective drug rebamipide in therapy for inflammatory and erosive-ulcerative lesions of the gastrointestinal tract |
title_sort | cytoprotective drug rebamipide in therapy for inflammatory and erosive ulcerative lesions of the gastrointestinal tract |
topic | gastric cytoprotection gastric ulcer prostaglandins cytokines helicobacter pylori helicobacter pylori-associated gastropathy enteropathy |
url | https://ter-arkhiv.ru/0040-3660/article/viewFile/31991/pdf |
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