Cell spheroids are as effective as single cells suspensions in the treatment of critical-sized bone defects

Cell spheroids are as effective as single cells suspensions in the treatment of critical-sized bone defects

Abstract Background Due to their multilineage potential and high proliferation rate, mesenchymal stem cells (MSC) indicate a sufficient alternative in regenerative medicine. In comparison to the commonly used 2-dimensional culturing method, culturing cells as spheroids stimulates the cell-cell commu...

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Bibliographic Details
Main Authors: Lisa Findeisen, Julia Bolte, Corina Vater, Cathleen Petzold, Mandy Quade, Lars Müller, Stuart B. Goodman, Stefan Zwingenberger
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
Critical-sized bone defect
Bone regeneration
Mesenchymal stromal cells
Cell spheroids
Online Access:https://doi.org/10.1186/s12891-021-04264-y

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