Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms.
Açaí (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Despite its claimed pharmacological and nutraceutical value, studies regarding the effects of açaí in vivo are limited. In this study, we use the Caenorhabditis elegans model to evaluate the in vivo ant...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3940722?pdf=render |
| _version_ | 1818035159896686592 |
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| author | Larissa de Freitas Bonomo David Nunes Silva Patrícia Ferreira Boasquivis Franciny Aparecida Paiva Joyce Ferreira da Costa Guerra Talita Alves Faria Martins Álvaro Gustavo de Jesus Torres Igor Thadeu Borges Raposo de Paula Washington Luiz Caneschi Philippe Jacolot Nicolas Grossin Frederic J Tessier Eric Boulanger Marcelo Eustáquio Silva Maria Lúcia Pedrosa Riva de Paula Oliveira |
| author_facet | Larissa de Freitas Bonomo David Nunes Silva Patrícia Ferreira Boasquivis Franciny Aparecida Paiva Joyce Ferreira da Costa Guerra Talita Alves Faria Martins Álvaro Gustavo de Jesus Torres Igor Thadeu Borges Raposo de Paula Washington Luiz Caneschi Philippe Jacolot Nicolas Grossin Frederic J Tessier Eric Boulanger Marcelo Eustáquio Silva Maria Lúcia Pedrosa Riva de Paula Oliveira |
| author_sort | Larissa de Freitas Bonomo |
| collection | DOAJ |
| description | Açaí (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Despite its claimed pharmacological and nutraceutical value, studies regarding the effects of açaí in vivo are limited. In this study, we use the Caenorhabditis elegans model to evaluate the in vivo antioxidant properties of açaí on an organismal level and to examine its mechanism of action. Supplementation with açaí aqueous extract (AAE) increased both oxidative and osmotic stress resistance independently of any effect on reproduction and development. AAE suppressed bacterial growth, but this antimicrobial property did not influence stress resistance. AAE-increased stress resistance was correlated with reduced ROS production, the prevention of sulfhydryl (SH) level reduction and gcs-1 activation under oxidative stress conditions. Our mechanistic studies indicated that AAE promotes oxidative stress resistance by acting through DAF-16 and the osmotic stress response pathway OSR-1/UNC-43/SEK-1. Finally, AAE increased polyglutamine protein aggregation and decreased proteasome activity. Our findings suggest that natural compounds available in AAE can improve the antioxidant status of a whole organism under certain conditions by direct and indirect mechanisms. |
| first_indexed | 2024-12-10T06:50:38Z |
| format | Article |
| id | doaj.art-df9e1fabab8546229e7a9860b2074a99 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:50:38Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-df9e1fabab8546229e7a9860b2074a992022-12-22T01:58:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e8993310.1371/journal.pone.0089933Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms.Larissa de Freitas BonomoDavid Nunes SilvaPatrícia Ferreira BoasquivisFranciny Aparecida PaivaJoyce Ferreira da Costa GuerraTalita Alves Faria MartinsÁlvaro Gustavo de Jesus TorresIgor Thadeu Borges Raposo de PaulaWashington Luiz CaneschiPhilippe JacolotNicolas GrossinFrederic J TessierEric BoulangerMarcelo Eustáquio SilvaMaria Lúcia PedrosaRiva de Paula OliveiraAçaí (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Despite its claimed pharmacological and nutraceutical value, studies regarding the effects of açaí in vivo are limited. In this study, we use the Caenorhabditis elegans model to evaluate the in vivo antioxidant properties of açaí on an organismal level and to examine its mechanism of action. Supplementation with açaí aqueous extract (AAE) increased both oxidative and osmotic stress resistance independently of any effect on reproduction and development. AAE suppressed bacterial growth, but this antimicrobial property did not influence stress resistance. AAE-increased stress resistance was correlated with reduced ROS production, the prevention of sulfhydryl (SH) level reduction and gcs-1 activation under oxidative stress conditions. Our mechanistic studies indicated that AAE promotes oxidative stress resistance by acting through DAF-16 and the osmotic stress response pathway OSR-1/UNC-43/SEK-1. Finally, AAE increased polyglutamine protein aggregation and decreased proteasome activity. Our findings suggest that natural compounds available in AAE can improve the antioxidant status of a whole organism under certain conditions by direct and indirect mechanisms.http://europepmc.org/articles/PMC3940722?pdf=render |
| spellingShingle | Larissa de Freitas Bonomo David Nunes Silva Patrícia Ferreira Boasquivis Franciny Aparecida Paiva Joyce Ferreira da Costa Guerra Talita Alves Faria Martins Álvaro Gustavo de Jesus Torres Igor Thadeu Borges Raposo de Paula Washington Luiz Caneschi Philippe Jacolot Nicolas Grossin Frederic J Tessier Eric Boulanger Marcelo Eustáquio Silva Maria Lúcia Pedrosa Riva de Paula Oliveira Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. PLoS ONE |
| title | Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. |
| title_full | Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. |
| title_fullStr | Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. |
| title_full_unstemmed | Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. |
| title_short | Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. |
| title_sort | acai euterpe oleracea mart modulates oxidative stress resistance in caenorhabditis elegans by direct and indirect mechanisms |
| url | http://europepmc.org/articles/PMC3940722?pdf=render |
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