The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease
Background: Most prevalent chronic liver disease in developed and developing nations is non-alcoholic fatty liver disease. From fatty liver, which often has benign, non-progressive clinical history, to non-alcoholic steatohepatitis, a more serious variant of fatty liver that can lead to cirrhosis a...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2023-12-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1058 |
| _version_ | 1797367572796014592 |
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| author | Muntadher Abdullah Raghad Jawad Al-Akayshee Kamal Breesam Lafta |
| author_facet | Muntadher Abdullah Raghad Jawad Al-Akayshee Kamal Breesam Lafta |
| author_sort | Muntadher Abdullah |
| collection | DOAJ |
| description |
Background: Most prevalent chronic liver disease in developed and developing nations is non-alcoholic fatty liver disease. From fatty liver, which often has benign, non-progressive clinical history, to non-alcoholic steatohepatitis, a more serious variant of fatty liver that can lead to cirrhosis and end-stage liver disease, non-alcoholic fatty liver disease encompasses broad spectrum of diseases. The gold standard for determining extent of hepatic fibrosis is still liver biopsy; however, number of noninvasive tests have been established to make diagnosis and assess effectiveness of treatment.
Objective: Aim of study was to assess effectiveness of the combination of fibroscan and noninvasive biochemical tests and scoring systems for assessing liver fibrosis.
Subjects and Methods: Cross-sectional prospective study conducted at outpatient clinic of Baghdad Gastroenterology and Hepatology Teaching Hospital from October 2018-March 2020. One hundred patients with fatty liver selected and subjected to specific questionnaires.
Results: One hundred patients with fatty liver studied; fifty-five (55%) males, forty-five (45%) females. Mean age was (45 ±12.24) years, females were significantly older. Mean stiffness score was 11.7(SD:5.29) KPa. Forty-six (46%) patients had advanced fibrosis. The Positive correlation between FibroScan examination results and the noninvasive scores results was significant, as well as there was significant positive correlation between age and stiffness score and significant negative correlation between platelet count and stiffness score.
Conclusions: This study showed that half patients showed advanced fibrosis, highlighting the need for early detection and management of fatty liver patients. Implementation of FibroScan with noninvasive fibrosis scoring tools has been shown to be helpful in this situation.
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| first_indexed | 2024-03-08T17:19:17Z |
| format | Article |
| id | doaj.art-df9e7a7999e7461c83aef36a0a5f44a7 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-03-08T17:19:17Z |
| publishDate | 2023-12-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-df9e7a7999e7461c83aef36a0a5f44a72024-01-03T09:07:33ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652023-12-0119310.47723/kcmj.v19i3.1058984The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease Muntadher Abdullah0Raghad Jawad Al-Akayshee1Kamal Breesam Lafta2Department of Medicine, Basrah College of Medicine, Basrah Gastroenterology and Hepatology Hospital, Basrah, IraqBaghdad Medical City, Baghdad Gastroenterology and Hepatology Teaching Hospital, Baghdad, IraqBasrah College of Medicine, Basrah Gastroenterology and Hepatology Hospital, Basrah, Iraq Background: Most prevalent chronic liver disease in developed and developing nations is non-alcoholic fatty liver disease. From fatty liver, which often has benign, non-progressive clinical history, to non-alcoholic steatohepatitis, a more serious variant of fatty liver that can lead to cirrhosis and end-stage liver disease, non-alcoholic fatty liver disease encompasses broad spectrum of diseases. The gold standard for determining extent of hepatic fibrosis is still liver biopsy; however, number of noninvasive tests have been established to make diagnosis and assess effectiveness of treatment. Objective: Aim of study was to assess effectiveness of the combination of fibroscan and noninvasive biochemical tests and scoring systems for assessing liver fibrosis. Subjects and Methods: Cross-sectional prospective study conducted at outpatient clinic of Baghdad Gastroenterology and Hepatology Teaching Hospital from October 2018-March 2020. One hundred patients with fatty liver selected and subjected to specific questionnaires. Results: One hundred patients with fatty liver studied; fifty-five (55%) males, forty-five (45%) females. Mean age was (45 ±12.24) years, females were significantly older. Mean stiffness score was 11.7(SD:5.29) KPa. Forty-six (46%) patients had advanced fibrosis. The Positive correlation between FibroScan examination results and the noninvasive scores results was significant, as well as there was significant positive correlation between age and stiffness score and significant negative correlation between platelet count and stiffness score. Conclusions: This study showed that half patients showed advanced fibrosis, highlighting the need for early detection and management of fatty liver patients. Implementation of FibroScan with noninvasive fibrosis scoring tools has been shown to be helpful in this situation. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1058Fibroscannon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisliver stiffness measurementtransient elastographyontrolled attenuation parameter |
| spellingShingle | Muntadher Abdullah Raghad Jawad Al-Akayshee Kamal Breesam Lafta The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease مجله كليه طب الكندي Fibroscan non-alcoholic fatty liver disease non-alcoholic steatohepatitis liver stiffness measurement transient elastography ontrolled attenuation parameter |
| title | The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease |
| title_full | The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease |
| title_fullStr | The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease |
| title_short | The Combination of Noninvasive Tests and Fibroscan for the Assessment of Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease |
| title_sort | combination of noninvasive tests and fibroscan for the assessment of liver fibrosis among patients with nonalcoholic fatty liver disease |
| topic | Fibroscan non-alcoholic fatty liver disease non-alcoholic steatohepatitis liver stiffness measurement transient elastography ontrolled attenuation parameter |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1058 |
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