Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study
Abstract Background Both genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population. Methods This case-control study...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-020-03479-6 |
| _version_ | 1818953194496065536 |
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| author | Xuefeng Pan Benjie Wei Hong Wang Lingyu Ma Zhaoli Du Ying Chen |
| author_facet | Xuefeng Pan Benjie Wei Hong Wang Lingyu Ma Zhaoli Du Ying Chen |
| author_sort | Xuefeng Pan |
| collection | DOAJ |
| description | Abstract Background Both genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population. Methods This case-control study involved 335 Han Chinese pregnant women, including 177 pregnant women with preeclampsia and 158 healthy controls. The preeclampsia group was further sub-grouped into early-onset preeclampsia (EOPE, n = 70)and late-onset preeclampsia (LOPE, n = 107. Three single nucleotide polymorphisms (SNPs), including FOXO3 (rs2232365, rs3761548), and TLR7 rs3853839 were genotyped by multiplex PCR for targeted next-generation sequencing. The χ2 test and multiple interaction effect analyses were performed to determine the association of three SNPs with serum lipid levels and thyroid function in women with preeclampsia. Results The genotype (CC vs. TT + CT) distribution of rs2232365 revealed a significant association with LOPE (P = 0.004, odds ratio = 3.525 (0.95 CI: 1.498–8.164)). No significant difference was found in the genotype and allele frequencies of rs3761548 and rs3853839 between controls and cases (P > 0.05). Moreover, the genotype CT/TT of rs2232365 was significantly correlated with increased TG/HDL levels in the LOPE group (p = 0.014). Conclusions The polymorphisms of rs2232365 are associated with the risk of LOPE and may modulate TG/HDL levels in pregnant women with LOPE. |
| first_indexed | 2024-12-20T10:02:24Z |
| format | Article |
| id | doaj.art-dfa3b06f6aa14124ac4c6dc97d2d066d |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-20T10:02:24Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-dfa3b06f6aa14124ac4c6dc97d2d066d2022-12-21T19:44:20ZengBMCBMC Pregnancy and Childbirth1471-23932020-12-0120111110.1186/s12884-020-03479-6Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic studyXuefeng Pan0Benjie Wei1Hong Wang2Lingyu Ma3Zhaoli Du4Ying Chen5Department of Obstetrics, The First Hospital of Jilin UniversityInstitute of Genetic Technology, Yinfeng Bilogical GroupDepartment of Obstetrics, The First Hospital of Jilin UniversityDepartment of Obstetrics, The First Hospital of Jilin UniversityInstitute of Genetic Technology, Yinfeng Bilogical GroupDepartment of Obstetrics, The First Hospital of Jilin UniversityAbstract Background Both genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population. Methods This case-control study involved 335 Han Chinese pregnant women, including 177 pregnant women with preeclampsia and 158 healthy controls. The preeclampsia group was further sub-grouped into early-onset preeclampsia (EOPE, n = 70)and late-onset preeclampsia (LOPE, n = 107. Three single nucleotide polymorphisms (SNPs), including FOXO3 (rs2232365, rs3761548), and TLR7 rs3853839 were genotyped by multiplex PCR for targeted next-generation sequencing. The χ2 test and multiple interaction effect analyses were performed to determine the association of three SNPs with serum lipid levels and thyroid function in women with preeclampsia. Results The genotype (CC vs. TT + CT) distribution of rs2232365 revealed a significant association with LOPE (P = 0.004, odds ratio = 3.525 (0.95 CI: 1.498–8.164)). No significant difference was found in the genotype and allele frequencies of rs3761548 and rs3853839 between controls and cases (P > 0.05). Moreover, the genotype CT/TT of rs2232365 was significantly correlated with increased TG/HDL levels in the LOPE group (p = 0.014). Conclusions The polymorphisms of rs2232365 are associated with the risk of LOPE and may modulate TG/HDL levels in pregnant women with LOPE.https://doi.org/10.1186/s12884-020-03479-6PreeclampsiaSingle nucleotide polymorphismrs2232365BMILipid metabolism |
| spellingShingle | Xuefeng Pan Benjie Wei Hong Wang Lingyu Ma Zhaoli Du Ying Chen Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study BMC Pregnancy and Childbirth Preeclampsia Single nucleotide polymorphism rs2232365 BMI Lipid metabolism |
| title | Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study |
| title_full | Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study |
| title_fullStr | Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study |
| title_full_unstemmed | Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study |
| title_short | Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study |
| title_sort | novel association between foxo3 rs2232365 polymorphism and late onset preeclampsia a case control candidate genetic study |
| topic | Preeclampsia Single nucleotide polymorphism rs2232365 BMI Lipid metabolism |
| url | https://doi.org/10.1186/s12884-020-03479-6 |
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