Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contrib...

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Bibliographic Details
Main Authors: Rathan Joy Komban, Anneli Strömberg, Adi Biram, Jakob Cervin, Cristina Lebrero-Fernández, Neil Mabbott, Ulf Yrlid, Ziv Shulman, Mats Bemark, Nils Lycke
Format: Article
Language:English
Published: Nature Portfolio 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10144-w
Description
Summary:Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.
ISSN:2041-1723

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