Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome
Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contrib...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10144-w |
| _version_ | 1818977916203040768 |
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| author | Rathan Joy Komban Anneli Strömberg Adi Biram Jakob Cervin Cristina Lebrero-Fernández Neil Mabbott Ulf Yrlid Ziv Shulman Mats Bemark Nils Lycke |
| author_facet | Rathan Joy Komban Anneli Strömberg Adi Biram Jakob Cervin Cristina Lebrero-Fernández Neil Mabbott Ulf Yrlid Ziv Shulman Mats Bemark Nils Lycke |
| author_sort | Rathan Joy Komban |
| collection | DOAJ |
| description | Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity. |
| first_indexed | 2024-12-20T16:35:20Z |
| format | Article |
| id | doaj.art-dfa3b986a6dc4e698df2c098d4517404 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:35:20Z |
| publishDate | 2019-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dfa3b986a6dc4e698df2c098d45174042022-12-21T19:33:11ZengNature PortfolioNature Communications2041-17232019-06-0110111510.1038/s41467-019-10144-wActivated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial domeRathan Joy Komban0Anneli Strömberg1Adi Biram2Jakob Cervin3Cristina Lebrero-Fernández4Neil Mabbott5Ulf Yrlid6Ziv Shulman7Mats Bemark8Nils Lycke9Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of GothenburgMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of GothenburgDepartment of Immunology, The Weizmann Institute of ScienceMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of GothenburgMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of GothenburgThe Roslin Institute, Edinburgh UniversityMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of GothenburgDepartment of Immunology, The Weizmann Institute of ScienceMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of GothenburgMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of GothenburgGut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.https://doi.org/10.1038/s41467-019-10144-w |
| spellingShingle | Rathan Joy Komban Anneli Strömberg Adi Biram Jakob Cervin Cristina Lebrero-Fernández Neil Mabbott Ulf Yrlid Ziv Shulman Mats Bemark Nils Lycke Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome Nature Communications |
| title | Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome |
| title_full | Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome |
| title_fullStr | Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome |
| title_full_unstemmed | Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome |
| title_short | Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome |
| title_sort | activated peyer s patch b cells sample antigen directly from m cells in the subepithelial dome |
| url | https://doi.org/10.1038/s41467-019-10144-w |
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