Early impairment of synaptic and intrinsic excitability in mice expressing ALS/dementia-linked mutant UBQLN2.

Early impairment of synaptic and intrinsic excitability in mice expressing ALS/dementia-linked mutant UBQLN2.

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are believed to represent the different outcomes of a common pathogenic mechanism. However, while researchers have intensely studied the involvement of motor neurons in the ALS/FTD syndrome, very little is known about the function...

Full description

Bibliographic Details
Main Authors: Daniel Radzicki, Erdong Liu, Han-Xiang Deng, Teepu Siddique, Marco Martina
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Action Potentials
Amyotrophic Lateral Sclerosis
Hippocampus
Synaptic Transmission
firing patterns
AHP potassium current
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00216/full

Similar Items

Similar Items