Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart Disease
Background: Valve replacement surgery (VRS) improves clinical outcomes in patients with severe rheumatic heart disease (RHD). However, lifelong anticoagulation and frequent monitoring are required, which potentially impacts health-related quality of life (HRQoL). In this study, we assessed the HRQoL...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2023-06-01
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| Series: | Global Heart |
| Subjects: | |
| Online Access: | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1205 |
| _version_ | 1827898887952662528 |
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| author | Mohammed A. M. Ahmed Twalib Aliku Judith Namuyonga Bernard Obongonyinge Hilda Tumwebaze Samalie M. Kitooleko Tom Mwambu Peter Lwabi Sulaiman Lubega |
| author_facet | Mohammed A. M. Ahmed Twalib Aliku Judith Namuyonga Bernard Obongonyinge Hilda Tumwebaze Samalie M. Kitooleko Tom Mwambu Peter Lwabi Sulaiman Lubega |
| author_sort | Mohammed A. M. Ahmed |
| collection | DOAJ |
| description | Background: Valve replacement surgery (VRS) improves clinical outcomes in patients with severe rheumatic heart disease (RHD). However, lifelong anticoagulation and frequent monitoring are required, which potentially impacts health-related quality of life (HRQoL). In this study, we assessed the HRQoL of people with RHD in Uganda following VRS. Methods: This was a hospital-based, cross-sectional study conducted between March and August 2021. Eligible participants were individuals who had VRS before the age of 18 years. The Pediatric Quality of Life Inventory–Cardiac Module (PedsQL-Cardiac module) was used to evaluate HRQoL. A total mean score of ≥ 80% was considered as optimal HRQoL. Results: Of the 83 eligible participants, 52 (60.5%) were female, with a median age of 18 (interquartile range: 14–22) years. Most participants had NYHA I functional status (n = 79, 92%). Most (n = 73, 92.4%) surgeries were performed outside of Uganda, and 61 (72.6%) were single mechanical valve replacement. Almost half (n = 45, 54%) expressed no concern about being on life-long warfarin therapy. However, 24 (29.3%) feared bleeding. The optimal mean score of cardiac-specific HRQoL was achieved in 50 (60.2%) of participants. Factors associated with optimal HRQoL were body mass index (BMI) (adjusted odds ratio (aOR), 1.2, 95% Confidence Interval: 1.1–1.3, p = 0.006), being afraid of bleeding or bruising (aOR: 1.5, 95% CI: 1.21–2.47, p = 0.004), acceptance of having an artificial valve (aOR: 2.7, 95% CI; 1.64–3.81, p < 0.001). Conclusion: HRQoL was optimal in about three in five participants following VRS. Increasing BMI and acceptance of artificial valve were significantly associated with optimal HRQoL. |
| first_indexed | 2024-03-12T23:10:02Z |
| format | Article |
| id | doaj.art-dfa69e36f86a41e485702b90f1264f7e |
| institution | Directory Open Access Journal |
| issn | 2211-8179 |
| language | English |
| last_indexed | 2024-03-12T23:10:02Z |
| publishDate | 2023-06-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Global Heart |
| spelling | doaj.art-dfa69e36f86a41e485702b90f1264f7e2023-07-18T08:15:39ZengUbiquity PressGlobal Heart2211-81792023-06-01181373710.5334/gh.12051186Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart DiseaseMohammed A. M. Ahmed0https://orcid.org/0000-0002-9176-0835Twalib Aliku1https://orcid.org/0000-0001-5920-8648Judith Namuyonga2https://orcid.org/0000-0002-4638-6928Bernard Obongonyinge3https://orcid.org/0000-0002-8015-5373Hilda Tumwebaze4https://orcid.org/0000-0002-2567-4226Samalie M. Kitooleko5https://orcid.org/0009-0001-4418-6500Tom Mwambu6https://orcid.org/0009-0007-8261-125XPeter Lwabi7https://orcid.org/0000-0002-2895-3626Sulaiman Lubega8https://orcid.org/0009-0009-6172-7784Department of Paediatric Cardiology, Uganda Heart Institute, Kampala, UG; Department of Paediatrics, Faculty of Medicine and Surgery, Mogadishu University, MogadishuDepartment of Paediatric Cardiology, Uganda Heart Institute, Kampala; School of Medicine, Uganda Christian University, MukonoDepartment of Paediatric Cardiology, Uganda Heart Institute, KampalaDepartment of Paediatric Cardiology, Uganda Heart Institute, KampalaDepartment of Paediatric Cardiology, Uganda Heart Institute, KampalaDepartment of Paediatric Cardiology, Uganda Heart Institute, KampalaDepartment of Adult Cardiovascular Surgery, Uganda heart institute, KampalaDepartment of Paediatric Cardiology, Uganda Heart Institute, KampalaDepartment of Paediatric Cardiology, Uganda Heart Institute, KampalaBackground: Valve replacement surgery (VRS) improves clinical outcomes in patients with severe rheumatic heart disease (RHD). However, lifelong anticoagulation and frequent monitoring are required, which potentially impacts health-related quality of life (HRQoL). In this study, we assessed the HRQoL of people with RHD in Uganda following VRS. Methods: This was a hospital-based, cross-sectional study conducted between March and August 2021. Eligible participants were individuals who had VRS before the age of 18 years. The Pediatric Quality of Life Inventory–Cardiac Module (PedsQL-Cardiac module) was used to evaluate HRQoL. A total mean score of ≥ 80% was considered as optimal HRQoL. Results: Of the 83 eligible participants, 52 (60.5%) were female, with a median age of 18 (interquartile range: 14–22) years. Most participants had NYHA I functional status (n = 79, 92%). Most (n = 73, 92.4%) surgeries were performed outside of Uganda, and 61 (72.6%) were single mechanical valve replacement. Almost half (n = 45, 54%) expressed no concern about being on life-long warfarin therapy. However, 24 (29.3%) feared bleeding. The optimal mean score of cardiac-specific HRQoL was achieved in 50 (60.2%) of participants. Factors associated with optimal HRQoL were body mass index (BMI) (adjusted odds ratio (aOR), 1.2, 95% Confidence Interval: 1.1–1.3, p = 0.006), being afraid of bleeding or bruising (aOR: 1.5, 95% CI: 1.21–2.47, p = 0.004), acceptance of having an artificial valve (aOR: 2.7, 95% CI; 1.64–3.81, p < 0.001). Conclusion: HRQoL was optimal in about three in five participants following VRS. Increasing BMI and acceptance of artificial valve were significantly associated with optimal HRQoL.https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1205rheumatic heart diseasevalve replacement surgeryhealth related quality of lifeuganda |
| spellingShingle | Mohammed A. M. Ahmed Twalib Aliku Judith Namuyonga Bernard Obongonyinge Hilda Tumwebaze Samalie M. Kitooleko Tom Mwambu Peter Lwabi Sulaiman Lubega Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart Disease Global Heart rheumatic heart disease valve replacement surgery health related quality of life uganda |
| title | Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart Disease |
| title_full | Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart Disease |
| title_fullStr | Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart Disease |
| title_full_unstemmed | Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart Disease |
| title_short | Health Related Quality of Life of Ugandan Children Following Valve Replacement Surgery for Rheumatic Heart Disease |
| title_sort | health related quality of life of ugandan children following valve replacement surgery for rheumatic heart disease |
| topic | rheumatic heart disease valve replacement surgery health related quality of life uganda |
| url | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1205 |
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