| Summary: | Intra-articular injections of hyaluronic acid are a valid treatment option for patients with osteoarthritis. Differences in purity, origin, and molecular weight may influence the efficacy and safety of hyaluronic acid products, therefore, we evaluated the safety, efficacy, and duration of improvements following a single intra-articular injection of a low-medium molecular weight hyaluronic acid product of bacterial synthesis, Sinovial® One, on patients with osteoarthritis of the knee. The double-blind study enrolled 21 patients (24 knees) with symptomatic knee osteoarthritis, classified into moderate, severe and very severe osteoarthritis using the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain functional Index and the Kellgren and Lawrence scales. At four months there was improvement in measured clinical parameters in 77.6% of the 24 treated knees, particularly in patients with moderate and severe osteoarthritis (improvement in 100% and 66.7%, respectively). No local or systemic adverse events were observed. These preliminary findings suggest that Sinovial® One is safe and effective for patients with knee osteoarthritis, providing long-lasting improvement in clinical parameters.
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