Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization

Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization

Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-c...

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Bibliographic Details
Main Authors: Dong Liu, Qianni Wu, Yuqiong Zhu, Yijun Liu, Xiuli Xie, Sihan Li, Haotian Lin, Weirong Chen, Fangming Zhu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
thermosensitive hydrogel
corneal neovascularization
metformin
subconjunctival injection
synergistic effect
Online Access:http://dx.doi.org/10.1080/10717544.2019.1609623

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