The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of Mice
Purpose The combined effect of acetic acid supplementation and endurance exercise training on fatty acid metabolism and skeletal muscle functions are not well known. Therefore, the purpose of this study was to investigate the effects of 8-week acetic acid administration with or without endurance exe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Korean |
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The Korean Society of Exercise Physiology
2021-02-01
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| Series: | 운동과학 |
| Subjects: | |
| Online Access: | http://www.ksep-es.org/upload/pdf/es-30-1-34.pdf |
| _version_ | 1818847701931917312 |
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| author | Dong-Won Lee Sung-Hee Oh Kyung-Oh Choi Jeong-Sun Ju |
| author_facet | Dong-Won Lee Sung-Hee Oh Kyung-Oh Choi Jeong-Sun Ju |
| author_sort | Dong-Won Lee |
| collection | DOAJ |
| description | Purpose The combined effect of acetic acid supplementation and endurance exercise training on fatty acid metabolism and skeletal muscle functions are not well known. Therefore, the purpose of this study was to investigate the effects of 8-week acetic acid administration with or without endurance exercise training on fatty acid metabolism and skeletal muscle functions using mice. Methods Fourty-eight male wild-type ICR mice (10-week old) were randomly divided into 4 groups: sedentary control (Sed+Con), sedentary sodium acetate (Sed+NaAc), exercise control (Exe+Con) and exercise sodium acetate (Exe+NaAc) groups. For acetic acid diet, sodium acetate was incorporated into the chow diet at 5% (w/w). For the exercise training, mice performed 4 days/week of 20 min treadmill running exercise training for 8 weeks. Following 8 weeks of combined treatments of acetic acid and endurance running exercise training, visceral fat mass and skeletal muscle mass, blood parameters, and the markers for fatty acid metabolism were analyzed. The results were analyzed with one-way ANOVA (p<.05) using the SPSS 21 program. Results Eight weeks of Exe+NaAc treatment significantly increased maximal running time compared with Sed+Con and Exe+Con groups (p<.05). Eight weeks of Exe+NaAc treatment significantly decreased fatty acid synthesis-related FAS (fatty acid synthase) protein levels compared with the Sed+Con group, and increased fatty acid oxidation-related CPT1B (carnitine palmitoyltransferase 1B) protein levels compared with Sed+Con and Sed+NaAc groups (p<.05). This combined treatment of acetic acid and endurance exercise training also increased AMPK activation compared with the Sed+Con and the Sed+NaAc groups (p<.05). Conclusions It was concluded that there were synergistic effects of the treatment of 8-week acetic acid supplementation and endurance exercise training on the reductions of body weight and visceral fat mass and an increase in endurance performance. |
| first_indexed | 2024-12-19T06:05:38Z |
| format | Article |
| id | doaj.art-dfabebcffbd4405c94242fa3418c56db |
| institution | Directory Open Access Journal |
| issn | 1226-1726 2384-0544 |
| language | Korean |
| last_indexed | 2024-12-19T06:05:38Z |
| publishDate | 2021-02-01 |
| publisher | The Korean Society of Exercise Physiology |
| record_format | Article |
| series | 운동과학 |
| spelling | doaj.art-dfabebcffbd4405c94242fa3418c56db2022-12-21T20:33:10ZkorThe Korean Society of Exercise Physiology운동과학1226-17262384-05442021-02-01301344210.15857/ksep.2021.30.1.34890The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of MiceDong-Won Lee0Sung-Hee Oh1Kyung-Oh Choi2Jeong-Sun Ju3 Department of Sports Science, The University of Suwon, Suwon, Korea Department of Sports Science, The University of Suwon, Suwon, Korea Department of Chemical and Material Engineering, The University of Suwon, Suwon, Korea Department of Sports Science, The University of Suwon, Suwon, KoreaPurpose The combined effect of acetic acid supplementation and endurance exercise training on fatty acid metabolism and skeletal muscle functions are not well known. Therefore, the purpose of this study was to investigate the effects of 8-week acetic acid administration with or without endurance exercise training on fatty acid metabolism and skeletal muscle functions using mice. Methods Fourty-eight male wild-type ICR mice (10-week old) were randomly divided into 4 groups: sedentary control (Sed+Con), sedentary sodium acetate (Sed+NaAc), exercise control (Exe+Con) and exercise sodium acetate (Exe+NaAc) groups. For acetic acid diet, sodium acetate was incorporated into the chow diet at 5% (w/w). For the exercise training, mice performed 4 days/week of 20 min treadmill running exercise training for 8 weeks. Following 8 weeks of combined treatments of acetic acid and endurance running exercise training, visceral fat mass and skeletal muscle mass, blood parameters, and the markers for fatty acid metabolism were analyzed. The results were analyzed with one-way ANOVA (p<.05) using the SPSS 21 program. Results Eight weeks of Exe+NaAc treatment significantly increased maximal running time compared with Sed+Con and Exe+Con groups (p<.05). Eight weeks of Exe+NaAc treatment significantly decreased fatty acid synthesis-related FAS (fatty acid synthase) protein levels compared with the Sed+Con group, and increased fatty acid oxidation-related CPT1B (carnitine palmitoyltransferase 1B) protein levels compared with Sed+Con and Sed+NaAc groups (p<.05). This combined treatment of acetic acid and endurance exercise training also increased AMPK activation compared with the Sed+Con and the Sed+NaAc groups (p<.05). Conclusions It was concluded that there were synergistic effects of the treatment of 8-week acetic acid supplementation and endurance exercise training on the reductions of body weight and visceral fat mass and an increase in endurance performance.http://www.ksep-es.org/upload/pdf/es-30-1-34.pdfacetic acidenduranceskeletal musclefatty acidfat metabolism |
| spellingShingle | Dong-Won Lee Sung-Hee Oh Kyung-Oh Choi Jeong-Sun Ju The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of Mice 운동과학 acetic acid endurance skeletal muscle fatty acid fat metabolism |
| title | The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of Mice |
| title_full | The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of Mice |
| title_fullStr | The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of Mice |
| title_full_unstemmed | The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of Mice |
| title_short | The Effects of 8-week Acetic Acid Feeding on Endurance Performance and Fat Metabolism in Skeletal Muscle of Mice |
| title_sort | effects of 8 week acetic acid feeding on endurance performance and fat metabolism in skeletal muscle of mice |
| topic | acetic acid endurance skeletal muscle fatty acid fat metabolism |
| url | http://www.ksep-es.org/upload/pdf/es-30-1-34.pdf |
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