mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses effector-like properties. PD-1–targeted therapies en...
Hauptverfasser: | , , , , , , , , , , , |
---|---|
Format: | Artikel |
Sprache: | English |
Veröffentlicht: |
American Society for Clinical Investigation
2023-01-01
|
Schriftenreihe: | The Journal of Clinical Investigation |
Schlagworte: | |
Online Zugang: | https://doi.org/10.1172/JCI160025 |