mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses effector-like properties. PD-1–targeted therapies en...

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Detaylı Bibliyografya
Asıl Yazarlar: Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2023-01-01
Seri Bilgileri:The Journal of Clinical Investigation
Konular:
Immunology
Infectious disease
Online Erişim:https://doi.org/10.1172/JCI160025

Internet

https://doi.org/10.1172/JCI160025

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