mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses effector-like properties. PD-1–targeted therapies en...

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Những tác giả chính: Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: American Society for Clinical Investigation 2023-01-01
Loạt:The Journal of Clinical Investigation
Những chủ đề:
Truy cập trực tuyến:https://doi.org/10.1172/JCI160025