mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses effector-like properties. PD-1–targeted therapies en...
| Main Authors: | , , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
American Society for Clinical Investigation
2023-01-01
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| 丛编: | The Journal of Clinical Investigation |
| 主题: | |
| 在线阅读: | https://doi.org/10.1172/JCI160025 |