Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective
Cancer is the second most reason for huge mortality in human life which has attributed to a drastic drift in anticancer drug discovery and development. Small molecules as anticancer agents have contributed tremendously for the treatment of cancer however plants based natural products have the cardin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142522000835 |
| _version_ | 1828178188237275136 |
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| author | Dipanjan Karati Dileep Kumar |
| author_facet | Dipanjan Karati Dileep Kumar |
| author_sort | Dipanjan Karati |
| collection | DOAJ |
| description | Cancer is the second most reason for huge mortality in human life which has attributed to a drastic drift in anticancer drug discovery and development. Small molecules as anticancer agents have contributed tremendously for the treatment of cancer however plants based natural products have the cardinal foundation for traditional medicine schemes and still offer relief to cancer patients. Medicinal plants are known for producing numerous bioactive secondary metabolites that have been used since antiquity due to their medicinal properties. Copious advantages of natural products over conventional anticancer drugs have expanded their use in the health care industry which has been witnessed by the extensive use of natural products in the treatment of multiple cancers. The pleiotropic effects of plant products on targets in multiple ways, phytochemicals are considered as suitable source candidates for anticancer drug design and development. In this review, we attempted to compile structural and functional attributes of natural products with an emphasis on their anticancer properties. |
| first_indexed | 2024-04-12T05:10:56Z |
| format | Article |
| id | doaj.art-dfadd1bf17a444ce8fcf644c4c7d1893 |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-04-12T05:10:56Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-dfadd1bf17a444ce8fcf644c4c7d18932022-12-22T03:46:45ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252022-09-014100123Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspectiveDipanjan Karati0Dileep Kumar1Department of Pharmaceutical Chemistry, Gitanjali College of Pharmacy, Birbhum, West Bengal, India, 731237Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, 411038, Maharashtra, India; Corresponding author.Cancer is the second most reason for huge mortality in human life which has attributed to a drastic drift in anticancer drug discovery and development. Small molecules as anticancer agents have contributed tremendously for the treatment of cancer however plants based natural products have the cardinal foundation for traditional medicine schemes and still offer relief to cancer patients. Medicinal plants are known for producing numerous bioactive secondary metabolites that have been used since antiquity due to their medicinal properties. Copious advantages of natural products over conventional anticancer drugs have expanded their use in the health care industry which has been witnessed by the extensive use of natural products in the treatment of multiple cancers. The pleiotropic effects of plant products on targets in multiple ways, phytochemicals are considered as suitable source candidates for anticancer drug design and development. In this review, we attempted to compile structural and functional attributes of natural products with an emphasis on their anticancer properties.http://www.sciencedirect.com/science/article/pii/S2667142522000835CancerPhytochemicalsMedicinal plantsStructure activity relationshipAnticancer activity |
| spellingShingle | Dipanjan Karati Dileep Kumar Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective Pharmacological Research - Modern Chinese Medicine Cancer Phytochemicals Medicinal plants Structure activity relationship Anticancer activity |
| title | Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective |
| title_full | Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective |
| title_fullStr | Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective |
| title_full_unstemmed | Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective |
| title_short | Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective |
| title_sort | exploring the structural and functional requirements of phyto compounds and their synthetic scaffolds as anticancer agents medicinal chemistry perspective |
| topic | Cancer Phytochemicals Medicinal plants Structure activity relationship Anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2667142522000835 |
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