Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice
Chronic diseases have been a leading cause of death worldwide, and polysaccharide supplementation is an effective therapeutic strategy for chronic diseases without adverse effects. In this study, the beneficial effect of <i>Laminaria japonica</i> fucoidan (LJF) on type 2 diabetes mellitu...
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MDPI AG
2022-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/1/33 |
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| author | Chenxi Zhang Jinhui Jia Panpan Zhang Weiyun Zheng Xiaoming Guo Chunqing Ai Shuang Song |
| author_facet | Chenxi Zhang Jinhui Jia Panpan Zhang Weiyun Zheng Xiaoming Guo Chunqing Ai Shuang Song |
| author_sort | Chenxi Zhang |
| collection | DOAJ |
| description | Chronic diseases have been a leading cause of death worldwide, and polysaccharide supplementation is an effective therapeutic strategy for chronic diseases without adverse effects. In this study, the beneficial effect of <i>Laminaria japonica</i> fucoidan (LJF) on type 2 diabetes mellitus (T2DM) was evaluated in streptozocin-treated mice. LJF ameliorated the symptoms of T2DM in a dose-dependent manner, involving reduction in weight loss, water intake, triglyceride, blood glucose, cholesterol and free fatty acids, and increases in high-density lipoprotein cholesterol, catalase, glucagon-like peptide-1, and superoxide dismutase. In addition, LJF regulated the balance between insulin resistance and insulin sensitivity, reduced islet necrosis and β-cell damage, and inhibited fat accumulation in T2DM mice. The protective effect of LJF on T2DM can be associated with modulation of the gut microbiota and metabolites, e.g., increases in <i>Lactobacillus</i> and <i>Allobaculum</i>. Untargeted and targeted metabolomics analysis showed that the microbiota metabolite profile was changed with LJF-induced microbiota alterations, mainly involving amino acids, glutathione, and glyoxylate and dicarboxylate metabolism pathways. This study indicates that LJF can be used as a prebiotic agent for the prevention and treatment of diabetes and microbiota-related diseases. |
| first_indexed | 2024-03-11T10:02:24Z |
| format | Article |
| id | doaj.art-dfae4312c6bd41358f464eee1dd6a982 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T10:02:24Z |
| publishDate | 2022-12-01 |
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| series | Foods |
| spelling | doaj.art-dfae4312c6bd41358f464eee1dd6a9822023-11-16T15:21:26ZengMDPI AGFoods2304-81582022-12-011213310.3390/foods12010033Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated MiceChenxi Zhang0Jinhui Jia1Panpan Zhang2Weiyun Zheng3Xiaoming Guo4Chunqing Ai5Shuang Song6School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, ChinaShenzhen Key Laboratory of Food Nutrition and Health, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, ChinaSchool of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, ChinaChronic diseases have been a leading cause of death worldwide, and polysaccharide supplementation is an effective therapeutic strategy for chronic diseases without adverse effects. In this study, the beneficial effect of <i>Laminaria japonica</i> fucoidan (LJF) on type 2 diabetes mellitus (T2DM) was evaluated in streptozocin-treated mice. LJF ameliorated the symptoms of T2DM in a dose-dependent manner, involving reduction in weight loss, water intake, triglyceride, blood glucose, cholesterol and free fatty acids, and increases in high-density lipoprotein cholesterol, catalase, glucagon-like peptide-1, and superoxide dismutase. In addition, LJF regulated the balance between insulin resistance and insulin sensitivity, reduced islet necrosis and β-cell damage, and inhibited fat accumulation in T2DM mice. The protective effect of LJF on T2DM can be associated with modulation of the gut microbiota and metabolites, e.g., increases in <i>Lactobacillus</i> and <i>Allobaculum</i>. Untargeted and targeted metabolomics analysis showed that the microbiota metabolite profile was changed with LJF-induced microbiota alterations, mainly involving amino acids, glutathione, and glyoxylate and dicarboxylate metabolism pathways. This study indicates that LJF can be used as a prebiotic agent for the prevention and treatment of diabetes and microbiota-related diseases.https://www.mdpi.com/2304-8158/12/1/33fucoidan<i>Laminaria japonica</i>gut microbiota and metabolites |
| spellingShingle | Chenxi Zhang Jinhui Jia Panpan Zhang Weiyun Zheng Xiaoming Guo Chunqing Ai Shuang Song Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice Foods fucoidan <i>Laminaria japonica</i> gut microbiota and metabolites |
| title | Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice |
| title_full | Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice |
| title_fullStr | Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice |
| title_full_unstemmed | Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice |
| title_short | Fucoidan from <i>Laminaria japonica</i> Ameliorates Type 2 Diabetes Mellitus in Association with Modulation of Gut Microbiota and Metabolites in Streptozocin-Treated Mice |
| title_sort | fucoidan from i laminaria japonica i ameliorates type 2 diabetes mellitus in association with modulation of gut microbiota and metabolites in streptozocin treated mice |
| topic | fucoidan <i>Laminaria japonica</i> gut microbiota and metabolites |
| url | https://www.mdpi.com/2304-8158/12/1/33 |
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