Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice

Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice

Abstract Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chronic administration of LNA‐miR‐29 into an atheroscle...

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Những tác giả chính: Victoria Ulrich, Noemi Rotllan, Elisa Araldi, Amelia Luciano, Philipp Skroblin, Mélanie Abonnenc, Paola Perrotta, Xiaoke Yin, Ashley Bauer, Kristen L Leslie, Pei Zhang, Binod Aryal, Rusty L Montgomery, Thomas Thum, Kathleen Martin, Yajaira Suarez, Manuel Mayr, Carlos Fernandez‐Hernando, William C Sessa
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Springer Nature 2016-05-01
Loạt:EMBO Molecular Medicine
Những chủ đề:
atherosclerosis
LNA
miR‐29
plaque
stability
Truy cập trực tuyến:https://doi.org/10.15252/emmm.201506031

Internet

https://doi.org/10.15252/emmm.201506031

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