Subunits of human condensins are potential therapeutic targets for cancers
Abstract The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are involved in some human cancers. This paper will first briefly discuss discoveries of hu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Cell Division |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13008-018-0035-3 |
| _version_ | 1818672850734678016 |
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| author | Hong-Zhen Wang Si-Han Yang Gui-Ying Li Xudong Cao |
| author_facet | Hong-Zhen Wang Si-Han Yang Gui-Ying Li Xudong Cao |
| author_sort | Hong-Zhen Wang |
| collection | DOAJ |
| description | Abstract The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are involved in some human cancers. This paper will first briefly discuss discoveries of human condensins, their components and structures, and their multiple cellular functions. This will be followed by reviews of most recent studies on subunits of human condensins and their dysregulations or mutations in human cancers. It can be concluded that many of these subunits have potentials to be novel targets for cancer therapies. However, hCAP-D2, a subunit of human condensin I, has not been directly documented to be associated with any human cancers to date. This review hypothesizes that hCAP-D2 can also be a potential therapeutic target for human cancers, and therefore that all subunits of human condensins are potential therapeutic targets for human cancers. |
| first_indexed | 2024-12-17T07:46:27Z |
| format | Article |
| id | doaj.art-dfaf9641c9db4d9891509a2909de0364 |
| institution | Directory Open Access Journal |
| issn | 1747-1028 |
| language | English |
| last_indexed | 2024-12-17T07:46:27Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj.art-dfaf9641c9db4d9891509a2909de03642022-12-21T21:58:00ZengBMCCell Division1747-10282018-02-0113111010.1186/s13008-018-0035-3Subunits of human condensins are potential therapeutic targets for cancersHong-Zhen Wang0Si-Han Yang1Gui-Ying Li2Xudong Cao3School of Life Sciences, Jilin Normal UniversitySchool of Life Sciences, Jilin Normal UniversityKey Laboratory for Molecular Enzymology and Engineering of The Ministry of Education, School of Life Sciences, Jilin UniversityDepartment of Chemical and Biological Engineering, University of OttawaAbstract The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are involved in some human cancers. This paper will first briefly discuss discoveries of human condensins, their components and structures, and their multiple cellular functions. This will be followed by reviews of most recent studies on subunits of human condensins and their dysregulations or mutations in human cancers. It can be concluded that many of these subunits have potentials to be novel targets for cancer therapies. However, hCAP-D2, a subunit of human condensin I, has not been directly documented to be associated with any human cancers to date. This review hypothesizes that hCAP-D2 can also be a potential therapeutic target for human cancers, and therefore that all subunits of human condensins are potential therapeutic targets for human cancers.http://link.springer.com/article/10.1186/s13008-018-0035-3Human condensinsSubunit of human condensinsCancerTherapeutic target |
| spellingShingle | Hong-Zhen Wang Si-Han Yang Gui-Ying Li Xudong Cao Subunits of human condensins are potential therapeutic targets for cancers Cell Division Human condensins Subunit of human condensins Cancer Therapeutic target |
| title | Subunits of human condensins are potential therapeutic targets for cancers |
| title_full | Subunits of human condensins are potential therapeutic targets for cancers |
| title_fullStr | Subunits of human condensins are potential therapeutic targets for cancers |
| title_full_unstemmed | Subunits of human condensins are potential therapeutic targets for cancers |
| title_short | Subunits of human condensins are potential therapeutic targets for cancers |
| title_sort | subunits of human condensins are potential therapeutic targets for cancers |
| topic | Human condensins Subunit of human condensins Cancer Therapeutic target |
| url | http://link.springer.com/article/10.1186/s13008-018-0035-3 |
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