Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid beta (Aβ) plaques. However, less than 5% of AD cases are familial, with many add...

Bibliografske podrobnosti
Main Authors:	James P. Higham, Bilal R. Malik, Edgar Buhl, Jennifer M. Dawson, Anna S. Ogier, Katie Lunnon, James J. L. Hodge
Format:	Article
Jezik:	English
Izdano:	Frontiers Media S.A. 2019-06-01
Serija:	Frontiers in Cellular Neuroscience
Teme:	Alzheimer’s disease Drosophila memory lifespan locomotion neurodegeneration
Online dostop:	https://www.frontiersin.org/article/10.3389/fncel.2019.00260/full

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