Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid beta (Aβ) plaques. However, less than 5% of AD cases are familial, with many add...

书目详细资料
Main Authors:	James P. Higham, Bilal R. Malik, Edgar Buhl, Jennifer M. Dawson, Anna S. Ogier, Katie Lunnon, James J. L. Hodge
格式:	文件
语言:	English
出版:	Frontiers Media S.A. 2019-06-01
丛编:	Frontiers in Cellular Neuroscience
主题:	Alzheimer’s disease Drosophila memory lifespan locomotion neurodegeneration
在线阅读:	https://www.frontiersin.org/article/10.3389/fncel.2019.00260/full

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