Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia
Aggrephagy is defined as the selective degradation of aggregated proteins by autophagosomes. Protein aggregation in organs and cells has been highlighted as a cause of multiple diseases, including neurodegenerative diseases, cardiac failure, and renal failure. Aggregates could pose a hazard for cell...
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/5/2432 |
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| author | Akitoshi Nakashima Tomoko Shima Sayaka Tsuda Aiko Aoki Mihoko Kawaguchi Atsushi Furuta Ippei Yasuda Satoshi Yoneda Akemi Yamaki-Ushijima Shi-Bin Cheng Surendra Sharma Shigeru Saito |
| author_facet | Akitoshi Nakashima Tomoko Shima Sayaka Tsuda Aiko Aoki Mihoko Kawaguchi Atsushi Furuta Ippei Yasuda Satoshi Yoneda Akemi Yamaki-Ushijima Shi-Bin Cheng Surendra Sharma Shigeru Saito |
| author_sort | Akitoshi Nakashima |
| collection | DOAJ |
| description | Aggrephagy is defined as the selective degradation of aggregated proteins by autophagosomes. Protein aggregation in organs and cells has been highlighted as a cause of multiple diseases, including neurodegenerative diseases, cardiac failure, and renal failure. Aggregates could pose a hazard for cell survival. Cells exhibit three main mechanisms against the accumulation of aggregates: protein refolding by upregulation of chaperones, reduction of protein overload by translational inhibition, and protein degradation by the ubiquitin–proteasome and autophagy–lysosome systems. Deletion of autophagy-related genes reportedly contributes to intracellular protein aggregation in vivo. Some proteins recognized in aggregates in preeclamptic placentas include those involved in neurodegenerative diseases. As aggregates are derived both intracellularly and extracellularly, special endocytosis for extracellular aggregates also employs the autophagy machinery. In this review, we discuss how the deficiency of aggrephagy and/or macroautophagy leads to poor placentation, resulting in preeclampsia or fetal growth restriction. |
| first_indexed | 2024-03-09T06:13:08Z |
| format | Article |
| id | doaj.art-dfb33799a018408eb80c96376573eef6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T06:13:08Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dfb33799a018408eb80c96376573eef62023-12-03T11:56:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01225243210.3390/ijms22052432Aggrephagy Deficiency in the Placenta: A New Pathogenesis of PreeclampsiaAkitoshi Nakashima0Tomoko Shima1Sayaka Tsuda2Aiko Aoki3Mihoko Kawaguchi4Atsushi Furuta5Ippei Yasuda6Satoshi Yoneda7Akemi Yamaki-Ushijima8Shi-Bin Cheng9Surendra Sharma10Shigeru Saito11Department of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Obstetrics and Gynecology, University of Toyama, Toyama 9300194, JapanDepartment of Pediatrics, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI 02905, USADepartment of Pediatrics, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI 02905, USAUniversity of Toyama, Toyama 9308555, JapanAggrephagy is defined as the selective degradation of aggregated proteins by autophagosomes. Protein aggregation in organs and cells has been highlighted as a cause of multiple diseases, including neurodegenerative diseases, cardiac failure, and renal failure. Aggregates could pose a hazard for cell survival. Cells exhibit three main mechanisms against the accumulation of aggregates: protein refolding by upregulation of chaperones, reduction of protein overload by translational inhibition, and protein degradation by the ubiquitin–proteasome and autophagy–lysosome systems. Deletion of autophagy-related genes reportedly contributes to intracellular protein aggregation in vivo. Some proteins recognized in aggregates in preeclamptic placentas include those involved in neurodegenerative diseases. As aggregates are derived both intracellularly and extracellularly, special endocytosis for extracellular aggregates also employs the autophagy machinery. In this review, we discuss how the deficiency of aggrephagy and/or macroautophagy leads to poor placentation, resulting in preeclampsia or fetal growth restriction.https://www.mdpi.com/1422-0067/22/5/2432aggrephagyaggresomeautophagyendoplasmic reticulum stressinflammationplacenta |
| spellingShingle | Akitoshi Nakashima Tomoko Shima Sayaka Tsuda Aiko Aoki Mihoko Kawaguchi Atsushi Furuta Ippei Yasuda Satoshi Yoneda Akemi Yamaki-Ushijima Shi-Bin Cheng Surendra Sharma Shigeru Saito Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia International Journal of Molecular Sciences aggrephagy aggresome autophagy endoplasmic reticulum stress inflammation placenta |
| title | Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia |
| title_full | Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia |
| title_fullStr | Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia |
| title_full_unstemmed | Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia |
| title_short | Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia |
| title_sort | aggrephagy deficiency in the placenta a new pathogenesis of preeclampsia |
| topic | aggrephagy aggresome autophagy endoplasmic reticulum stress inflammation placenta |
| url | https://www.mdpi.com/1422-0067/22/5/2432 |
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