A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.
Pituitary Prolactin (PRL) and Growth Hormone (GH) are separately controlled and sub-serve different purposes. Surprisingly, we demonstrate that extra-pituitary expression in the adult mammalian central nervous system (CNS) is coordinated at mRNA and protein levels. However this was not a uniform eff...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4760942?pdf=render |
| _version_ | 1818023624536227840 |
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| author | Nathalie Daude Inyoul Lee Taek-Kyun Kim Christopher Janus John Paul Glaves Hristina Gapeshina Jing Yang Brian D Sykes George A Carlson Leroy E Hood David Westaway |
| author_facet | Nathalie Daude Inyoul Lee Taek-Kyun Kim Christopher Janus John Paul Glaves Hristina Gapeshina Jing Yang Brian D Sykes George A Carlson Leroy E Hood David Westaway |
| author_sort | Nathalie Daude |
| collection | DOAJ |
| description | Pituitary Prolactin (PRL) and Growth Hormone (GH) are separately controlled and sub-serve different purposes. Surprisingly, we demonstrate that extra-pituitary expression in the adult mammalian central nervous system (CNS) is coordinated at mRNA and protein levels. However this was not a uniform effect within populations, such that wide inter-individual variation was superimposed on coordinate PRL/GH expression. Up to 44% of individuals in healthy cohorts of mice and rats showed protein levels above the norm and coordinated expression of PRL and GH transcripts above baseline occurred in the amygdala, frontal lobe and hippocampus of 10% of human subjects. High levels of PRL and GH present in post mortem tissue were often presaged by altered responses in fear conditioning and stress induced hyperthermia behavioral tests. Our data define a common phenotype polymorphism in healthy mammalian brains, and, given the pleiotropic effects known for circulating PRL and GH, further consequences of coordinated CNS over-expression may await discovery. |
| first_indexed | 2024-12-10T03:47:17Z |
| format | Article |
| id | doaj.art-dfb3519b1b0a4b96a78cfdb047547dec |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T03:47:17Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dfb3519b1b0a4b96a78cfdb047547dec2022-12-22T02:03:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014941010.1371/journal.pone.0149410A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.Nathalie DaudeInyoul LeeTaek-Kyun KimChristopher JanusJohn Paul GlavesHristina GapeshinaJing YangBrian D SykesGeorge A CarlsonLeroy E HoodDavid WestawayPituitary Prolactin (PRL) and Growth Hormone (GH) are separately controlled and sub-serve different purposes. Surprisingly, we demonstrate that extra-pituitary expression in the adult mammalian central nervous system (CNS) is coordinated at mRNA and protein levels. However this was not a uniform effect within populations, such that wide inter-individual variation was superimposed on coordinate PRL/GH expression. Up to 44% of individuals in healthy cohorts of mice and rats showed protein levels above the norm and coordinated expression of PRL and GH transcripts above baseline occurred in the amygdala, frontal lobe and hippocampus of 10% of human subjects. High levels of PRL and GH present in post mortem tissue were often presaged by altered responses in fear conditioning and stress induced hyperthermia behavioral tests. Our data define a common phenotype polymorphism in healthy mammalian brains, and, given the pleiotropic effects known for circulating PRL and GH, further consequences of coordinated CNS over-expression may await discovery.http://europepmc.org/articles/PMC4760942?pdf=render |
| spellingShingle | Nathalie Daude Inyoul Lee Taek-Kyun Kim Christopher Janus John Paul Glaves Hristina Gapeshina Jing Yang Brian D Sykes George A Carlson Leroy E Hood David Westaway A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. PLoS ONE |
| title | A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. |
| title_full | A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. |
| title_fullStr | A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. |
| title_full_unstemmed | A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. |
| title_short | A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. |
| title_sort | common phenotype polymorphism in mammalian brains defined by concomitant production of prolactin and growth hormone |
| url | http://europepmc.org/articles/PMC4760942?pdf=render |
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