Efek Pemberian Virgin Coconut Oil (Cocos nucifera) terhadap Dislipidemia pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diberi Diet Tinggi Kolesterol
Dyslipidemia is a lipid metabolism disorder followed by high total cholesterol level, high LDL cholesterol level, high tryglyceride level and low HDL cholesterol level. Virgin coconut oil (VCO) contains 92% saturated fat that is associated with an increased risk of cardiovascular disease. Not all sa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa
2016-11-01
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| Series: | WMJ (Warmadewa Medical Journal) |
| Subjects: | |
| Online Access: | https://www.ejournal.warmadewa.ac.id/index.php/warmadewa_medical_journal/article/view/28 |
| Summary: | Dyslipidemia is a lipid metabolism disorder followed by high total cholesterol level, high LDL cholesterol level, high tryglyceride level and low HDL cholesterol level. Virgin coconut oil (VCO) contains 92% saturated fat that is associated with an increased risk of cardiovascular disease. Not all saturated fatty acids are bad for health. VCO consist of medium chain triglycerides (MCTs) and polyphenol components that work synergistically in preventing dyslipidemia. This research was aimed to determine the usefulness of VCO as an alternative to prevent dyslipidemia in male wistar rats fed with high cholesterol diet. This study was a true experimental research with randomized post-test only control group design using 36 male rats. All samples were given a high cholesterol diet and were divided into 2 groups randomly: a control group were given a placebo (distilled water) 0,8 ml/ day and a treatment group were given VCO 0,8 ml/ 200gram weight/ day for 28 days. The results showed that the treatment group had a significantly lower total cholesterol levels compared to the control group (113,49±4,31 mg/dl vs 222,61±6,41 mg/dl) (p<0,05). The treatment group had a significantly lower triglycerides levels compared to the control group (91,46±5,56 mg/dl vs 153,51±5,40 mg/dl) (p<0,05). The treatment group had a significantly lower LDL cholesterol levels compared to the control group (37,94±3,32 mg/dl vs 71,25±2,76 mg/dl) (p<0,05). The treatment group had a significantly higher HDL cholesterol levels compared to the control group (41,62±1,58 mg/dl vs 25,02±2,59 mg/dl) (p<0,05). This research concluded that virgin coconut oil was proved in preventing dyslipidemia in male wistar rats fed with high cholesterol diet. |
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| ISSN: | 2527-4627 2579-9010 |