Annexin A1: A Bane or a Boon in Cancer? A Systematic Review
Annexin A1 has been extensively investigated as an anti-inflammatory protein, but its role in different types of cancer has not been consolidated in a single systematic review to date. Thus, the aim of this paper is to systematically review and critically analyse 18 studies (in-vivo and in-vitro) to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/16/3700 |
| _version_ | 1797558268906700800 |
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| author | Thanusha Ganesan Ajantha Sinniah Zaridatul Aini Ibrahim Zamri Chik Mohammed Abdullah Alshawsh |
| author_facet | Thanusha Ganesan Ajantha Sinniah Zaridatul Aini Ibrahim Zamri Chik Mohammed Abdullah Alshawsh |
| author_sort | Thanusha Ganesan |
| collection | DOAJ |
| description | Annexin A1 has been extensively investigated as an anti-inflammatory protein, but its role in different types of cancer has not been consolidated in a single systematic review to date. Thus, the aim of this paper is to systematically review and critically analyse 18 studies (in-vivo and in-vitro) to consolidate, in a concerted manner, all the information on differential expression of Annexin A1 in different types of cancer and the role this protein plays in tumorigenesis. Pubmed, Scopus, Web of Science, and ScienceDirect were used for the literature search and the keywords used are “annexin A1,” “lipocortin 1,” “cancer,” “malignancy,” “neoplasm,” “neoplasia,” and “tumor.” A total of 1128 articles were retrieved by implementing a standard search strategy subjected to meticulous screening processes and 442 articles were selected for full article screening. A total of 18 articles that adhered to the inclusion criteria were included in the systematic review and these articles possessed low to moderate bias. These studies showed a strong correlation between Annexin A1 expression and cancer progression via modulation of various cancer-associated pathways. Differential expression of Annexin A1 is shown to play a role in cellular proliferation, metastasis, lymphatic invasion, and development of resistance to anti-cancer treatment. Meta-analysis in the future may provide a statistically driven association between Annexin A1 expression and malignancy progression. |
| first_indexed | 2024-03-10T17:27:50Z |
| format | Article |
| id | doaj.art-dfb5437f69d446588581985f6f763539 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T17:27:50Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-dfb5437f69d446588581985f6f7635392023-11-20T10:06:56ZengMDPI AGMolecules1420-30492020-08-012516370010.3390/molecules25163700Annexin A1: A Bane or a Boon in Cancer? A Systematic ReviewThanusha Ganesan0Ajantha Sinniah1Zaridatul Aini Ibrahim2Zamri Chik3Mohammed Abdullah Alshawsh4Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaAnnexin A1 has been extensively investigated as an anti-inflammatory protein, but its role in different types of cancer has not been consolidated in a single systematic review to date. Thus, the aim of this paper is to systematically review and critically analyse 18 studies (in-vivo and in-vitro) to consolidate, in a concerted manner, all the information on differential expression of Annexin A1 in different types of cancer and the role this protein plays in tumorigenesis. Pubmed, Scopus, Web of Science, and ScienceDirect were used for the literature search and the keywords used are “annexin A1,” “lipocortin 1,” “cancer,” “malignancy,” “neoplasm,” “neoplasia,” and “tumor.” A total of 1128 articles were retrieved by implementing a standard search strategy subjected to meticulous screening processes and 442 articles were selected for full article screening. A total of 18 articles that adhered to the inclusion criteria were included in the systematic review and these articles possessed low to moderate bias. These studies showed a strong correlation between Annexin A1 expression and cancer progression via modulation of various cancer-associated pathways. Differential expression of Annexin A1 is shown to play a role in cellular proliferation, metastasis, lymphatic invasion, and development of resistance to anti-cancer treatment. Meta-analysis in the future may provide a statistically driven association between Annexin A1 expression and malignancy progression.https://www.mdpi.com/1420-3049/25/16/3700Annexin A1lipocortin 1cancergene expressionsystematic review |
| spellingShingle | Thanusha Ganesan Ajantha Sinniah Zaridatul Aini Ibrahim Zamri Chik Mohammed Abdullah Alshawsh Annexin A1: A Bane or a Boon in Cancer? A Systematic Review Molecules Annexin A1 lipocortin 1 cancer gene expression systematic review |
| title | Annexin A1: A Bane or a Boon in Cancer? A Systematic Review |
| title_full | Annexin A1: A Bane or a Boon in Cancer? A Systematic Review |
| title_fullStr | Annexin A1: A Bane or a Boon in Cancer? A Systematic Review |
| title_full_unstemmed | Annexin A1: A Bane or a Boon in Cancer? A Systematic Review |
| title_short | Annexin A1: A Bane or a Boon in Cancer? A Systematic Review |
| title_sort | annexin a1 a bane or a boon in cancer a systematic review |
| topic | Annexin A1 lipocortin 1 cancer gene expression systematic review |
| url | https://www.mdpi.com/1420-3049/25/16/3700 |
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