Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada
Abstract Background Sensitization to common environmental aeroallergens plays a significant role in the pathogenesis and severity of respiratory allergic disorders, specifically asthma and allergic rhinitis. Understanding sensitization patterns helps clinicians tailor care more effectively. This stu...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | http://link.springer.com/article/10.1186/s13223-019-0320-y |
| _version_ | 1818216860244508672 |
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| author | Hanan Ahmed Maria B. Ospina Kyriaki Sideri Harissios Vliagoftis |
| author_facet | Hanan Ahmed Maria B. Ospina Kyriaki Sideri Harissios Vliagoftis |
| author_sort | Hanan Ahmed |
| collection | DOAJ |
| description | Abstract Background Sensitization to common environmental aeroallergens plays a significant role in the pathogenesis and severity of respiratory allergic disorders, specifically asthma and allergic rhinitis. Understanding sensitization patterns helps clinicians tailor care more effectively. This study examines patterns of sensitization to aeroallergens in subjects suspected of having an allergic disease in Edmonton and catchment area. Methods Retrospective chart review of skin prick test (SPT) results to 11 environmental aeroallergens performed between January 1st and June 30th 2014 at a University-based clinic, where patients are referred for SPT by allergists, respirologists, otolaryngologists, internists and general practitioners. Potential differences in aeroallergen sensitization patterns were evaluated. Results A total of 623 patients (36.9% males; 63.1% females), aged 4–84 years (mean age 38.6 years) had SPT done, of which 438 (70.3%) had a positive test for at least one aeroallergen (atopy). There were no significant sex differences in the frequency of atopy (males: 71.3% versus females: 69.7%; p = 0.373). The frequency of sensitivity to particular allergens among atopic subjects was: cat (53.1%), house dust mites (50.3%), grass (39.2%), birch (23.7%), alternaria (23.7%), dog (17.3%), poplar (12.1%), cedar (9.6%), aspergillus (9.6%), hormodendrum (8%), and penicillium (6.2%). Of 438 atopic patients, 110 (25.1%) were mono sensitized, 199 (45.4%) oligosensitized (2–3 allergens), and 129 (29.5%) polysensitized (≥ 4 allergens). There were no significant differences between males and females in the odds of being oligo-sensitized (OR: 0.95; 95% CI 0.58, 1.57). Polysensitization was significantly more frequent in males 37.2% than in females 24.8%; (OR: 0.95; 95% CI 0.58, 1.57). Conclusion Cat is the most frequent perennial allergen and timothy grass pollen the most frequent seasonal allergen in Edmonton and catchment area. There was no significant difference in the frequency of atopy between males and females. However, males were more likely to be polysensitized compared to females. |
| first_indexed | 2024-12-12T06:58:41Z |
| format | Article |
| id | doaj.art-dfb709d81d8e41bd8cfb469fc0cdcd76 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-12-12T06:58:41Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-dfb709d81d8e41bd8cfb469fc0cdcd762022-12-22T00:33:53ZengBMCAllergy, Asthma & Clinical Immunology1710-14922019-02-011511610.1186/s13223-019-0320-yRetrospective analysis of aeroallergen’s sensitization patterns in Edmonton, CanadaHanan Ahmed0Maria B. Ospina1Kyriaki Sideri2Harissios Vliagoftis3Department of Medicine, McMaster UniversityDepartments of Obstetrics & Gynecology and MedicineDivision of Pulmonary Medicine, Department of Medicine, and Alberta Respiratory Center, University of AlbertaDivision of Pulmonary Medicine, Department of Medicine, and Alberta Respiratory Center, University of AlbertaAbstract Background Sensitization to common environmental aeroallergens plays a significant role in the pathogenesis and severity of respiratory allergic disorders, specifically asthma and allergic rhinitis. Understanding sensitization patterns helps clinicians tailor care more effectively. This study examines patterns of sensitization to aeroallergens in subjects suspected of having an allergic disease in Edmonton and catchment area. Methods Retrospective chart review of skin prick test (SPT) results to 11 environmental aeroallergens performed between January 1st and June 30th 2014 at a University-based clinic, where patients are referred for SPT by allergists, respirologists, otolaryngologists, internists and general practitioners. Potential differences in aeroallergen sensitization patterns were evaluated. Results A total of 623 patients (36.9% males; 63.1% females), aged 4–84 years (mean age 38.6 years) had SPT done, of which 438 (70.3%) had a positive test for at least one aeroallergen (atopy). There were no significant sex differences in the frequency of atopy (males: 71.3% versus females: 69.7%; p = 0.373). The frequency of sensitivity to particular allergens among atopic subjects was: cat (53.1%), house dust mites (50.3%), grass (39.2%), birch (23.7%), alternaria (23.7%), dog (17.3%), poplar (12.1%), cedar (9.6%), aspergillus (9.6%), hormodendrum (8%), and penicillium (6.2%). Of 438 atopic patients, 110 (25.1%) were mono sensitized, 199 (45.4%) oligosensitized (2–3 allergens), and 129 (29.5%) polysensitized (≥ 4 allergens). There were no significant differences between males and females in the odds of being oligo-sensitized (OR: 0.95; 95% CI 0.58, 1.57). Polysensitization was significantly more frequent in males 37.2% than in females 24.8%; (OR: 0.95; 95% CI 0.58, 1.57). Conclusion Cat is the most frequent perennial allergen and timothy grass pollen the most frequent seasonal allergen in Edmonton and catchment area. There was no significant difference in the frequency of atopy between males and females. However, males were more likely to be polysensitized compared to females.http://link.springer.com/article/10.1186/s13223-019-0320-yAeroallergensSensitizationAtopySkin prick testing |
| spellingShingle | Hanan Ahmed Maria B. Ospina Kyriaki Sideri Harissios Vliagoftis Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada Allergy, Asthma & Clinical Immunology Aeroallergens Sensitization Atopy Skin prick testing |
| title | Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada |
| title_full | Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada |
| title_fullStr | Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada |
| title_full_unstemmed | Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada |
| title_short | Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada |
| title_sort | retrospective analysis of aeroallergen s sensitization patterns in edmonton canada |
| topic | Aeroallergens Sensitization Atopy Skin prick testing |
| url | http://link.springer.com/article/10.1186/s13223-019-0320-y |
| work_keys_str_mv | AT hananahmed retrospectiveanalysisofaeroallergenssensitizationpatternsinedmontoncanada AT mariabospina retrospectiveanalysisofaeroallergenssensitizationpatternsinedmontoncanada AT kyriakisideri retrospectiveanalysisofaeroallergenssensitizationpatternsinedmontoncanada AT harissiosvliagoftis retrospectiveanalysisofaeroallergenssensitizationpatternsinedmontoncanada |