Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's disease
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Research has recently found that both animal models and patients with PD have circadian dysfunction, accompanied by abnormal expression of circadian genes and proteins, which implies that the circadian clock plays a...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024007837 |
| _version_ | 1797328628472610816 |
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| author | Jiahua Huang Wenwei Li |
| author_facet | Jiahua Huang Wenwei Li |
| author_sort | Jiahua Huang |
| collection | DOAJ |
| description | Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Research has recently found that both animal models and patients with PD have circadian dysfunction, accompanied by abnormal expression of circadian genes and proteins, which implies that the circadian clock plays a crucial role in PD etiopathogenesis. In addition, a strong relationship between NLRP3 inflammasome signaling and PD has been observed. Meanwhile, the activation of the NLRP3 inflammasome is highly relevant to dysfunctions of the molecular clock. Therefore, alleviating the neuroinflammation caused by NLRP3 inflammasome signaling by adjusting the abnormal molecular clock may be a potential strategy for preventing and treating PD. In this article, we have reviewed the potential or direct relationship between abnormalities of the circadian clock and NLRP3 inflammasome signaling in PD. |
| first_indexed | 2024-03-08T06:54:26Z |
| format | Article |
| id | doaj.art-dfb714f11dae458f8801556b29fabf75 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:54:26Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-dfb714f11dae458f8801556b29fabf752024-02-03T06:38:22ZengElsevierHeliyon2405-84402024-01-01102e24752Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's diseaseJiahua Huang0Wenwei Li1Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, 201500, Shanghai, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, 201500, Shanghai, ChinaLaboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, 201500, Shanghai, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, 201500, Shanghai, China; Corresponding author. Department of Neurology, Shanghai Public Health Clinical Center, and Institute of Neurology, Institute of Integrative Medicine, Fudan University, Shanghai, 201500, China.Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Research has recently found that both animal models and patients with PD have circadian dysfunction, accompanied by abnormal expression of circadian genes and proteins, which implies that the circadian clock plays a crucial role in PD etiopathogenesis. In addition, a strong relationship between NLRP3 inflammasome signaling and PD has been observed. Meanwhile, the activation of the NLRP3 inflammasome is highly relevant to dysfunctions of the molecular clock. Therefore, alleviating the neuroinflammation caused by NLRP3 inflammasome signaling by adjusting the abnormal molecular clock may be a potential strategy for preventing and treating PD. In this article, we have reviewed the potential or direct relationship between abnormalities of the circadian clock and NLRP3 inflammasome signaling in PD.http://www.sciencedirect.com/science/article/pii/S2405844024007837Circadian rhythmNLRP3 inflammasomeParkinson's disease |
| spellingShingle | Jiahua Huang Wenwei Li Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's disease Heliyon Circadian rhythm NLRP3 inflammasome Parkinson's disease |
| title | Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's disease |
| title_full | Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's disease |
| title_fullStr | Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's disease |
| title_full_unstemmed | Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's disease |
| title_short | Molecular crosstalk between circadian clock and NLRP3 inflammasome signaling in Parkinson's disease |
| title_sort | molecular crosstalk between circadian clock and nlrp3 inflammasome signaling in parkinson s disease |
| topic | Circadian rhythm NLRP3 inflammasome Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024007837 |
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